Friday, 10th April - h 14:00
Seminars room, NICO
Building up cortical organization: molecular and cellular mechanisms
Institute of Biology Valrose, University of Nice Sophia-Antipolis
The timing and proper formation of the neocortex is genetically programmed during development and can be profoundly altered by a number of abnormal genes that control regionalization, proliferation, differentiation and cell migration. In addition, thalamocortical inputs are important in shaping area-specific functional properties, possibly through activity-dependent mechanisms.
The lab is interested in understanding how regional identity, once established at progenitors level, is maintained in differentiated cortical pyramidal neurons during corticogenesis, and whether specific neuronal sub-populations or cortical circuits are peculiar of distinct functional neocortical areas. We are interested in a family of transcription factors, the COUP-TF family, which are involved in regional and cell-type specification of the dorsal and ventral telencephalon during development. Our recent data illustrate that COUP-TFI regulates different phases of cortical development in generating specific cell types in each brain region according to precise time schedules and to its region- and temporal-specific expression gradient.
During my presentation, I will do an overview on how transcription factors, including the COUP-TFs, can control the early and late organization of the cerebral cortex by acting on regionalisation, cell migration, connectivity, cell-type specification and neuronal activity. I will also illustrate some molecular and cellular mechanisms underlying cell-type specificity and morphological maturation across cortical areas, with particular emphasis on layer V projection neurons. Finally, I will speculate on how spontaneous neural activity could participate in setting up area-dependent neuronal circuits in the immature neocortex.
Host: Silvia De Marchis
I nostri giovani ricercatori aggiornano i colleghi sulle loro ricerche. Appuntamento ogni due venerdì.
Since 2001, this meeting represented an important event for basic and clinical researchers working on this emerging scientific topic. We will address state-of-the-art approaches in the field of steroids and nervous system, including behavior, epigenetics, genomic and non-genomic actions, the vitamin D, neurodegenerative and psychiatric disorders, and the interference among endocrine disruptors and steroid signaling.
Il gene COUP-TFI controlla che le staminali producano la giusta quantità di nuovi neuroni o astrociti. Un eccesso dei secondi è la conseguenza di processi infiammatori associati a patologie tra cui l’Alzheimer. La scoperta del team guidato da Silvia De Marchis, del nostro gruppo di Neurogenesi adulta.