Friday, 10th April - h 14:00
Seminars room, NICO
Building up cortical organization: molecular and cellular mechanisms
Institute of Biology Valrose, University of Nice Sophia-Antipolis
The timing and proper formation of the neocortex is genetically programmed during development and can be profoundly altered by a number of abnormal genes that control regionalization, proliferation, differentiation and cell migration. In addition, thalamocortical inputs are important in shaping area-specific functional properties, possibly through activity-dependent mechanisms.
The lab is interested in understanding how regional identity, once established at progenitors level, is maintained in differentiated cortical pyramidal neurons during corticogenesis, and whether specific neuronal sub-populations or cortical circuits are peculiar of distinct functional neocortical areas. We are interested in a family of transcription factors, the COUP-TF family, which are involved in regional and cell-type specification of the dorsal and ventral telencephalon during development. Our recent data illustrate that COUP-TFI regulates different phases of cortical development in generating specific cell types in each brain region according to precise time schedules and to its region- and temporal-specific expression gradient.
During my presentation, I will do an overview on how transcription factors, including the COUP-TFs, can control the early and late organization of the cerebral cortex by acting on regionalisation, cell migration, connectivity, cell-type specification and neuronal activity. I will also illustrate some molecular and cellular mechanisms underlying cell-type specificity and morphological maturation across cortical areas, with particular emphasis on layer V projection neurons. Finally, I will speculate on how spontaneous neural activity could participate in setting up area-dependent neuronal circuits in the immature neocortex.
Host: Silvia De Marchis
Events & Meetings
Our young researchers present their work to collegues. From January to December, every two weeks, on friday at 2:00 pm
Seminars Room, NICO
The main goal of the BraYn initiative is to organize a scientific conference involving different laboratories across Italy and Europe where young researchers, especially PhD students and junior postdocs, can share their knowledge, skills and ideas to establish new collaborations between different research groups.