Friday, May 15th 2015 - h. 14:00
Seminar Room, NICO
Time-dependent structural, functional and behavioural changes induced by acute stress at excitatory synapses in prefrontal and frontal cortex
Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission
Department of Pharmacological and Biomolecular Sciences, University of Milan
Stress deeply affects gene regulation, neurotransmission and synaptic morphology, and activate a stress response to restore homeostasis. However, when stress exposure is chronic, uncontrollable, or overwhelming, it represents a major risk factor for many diseases, including neuropsychiatric disorders.
Intriguingly, modifications of the glutamatergic system induced by stress in the prefrontal cortex seem to be biphasic. Indeed, while the fast response to stress suggests an enhancement in the number of excitatory synapses, synaptic transmission and working memory, long-term adaptive changes, including those consequent to chronic stress, induce opposite effects.
The identification of neural mechanisms underling resilience and vulnerability to stress is of crucial importance in the understanding of neuropsychiatric disorders pathophysiology and in the development of improved treatments.
Host: Alessandro Vercelli
Le ultime novità nella Microscopia Correlativa Multi-modale. Registrazione obbligatoria.
Since 2001, this meeting represented an important event for basic and clinical researchers working on this emerging scientific topic. We will address state-of-the-art approaches in the field of steroids and nervous system, including behavior, epigenetics, genomic and non-genomic actions, the vitamin D, neurodegenerative and psychiatric disorders, and the interference among endocrine disruptors and steroid signaling.
L’inibizione della proteina JNK rallenta la progressione della malattia che colpisce i motoneuroni ed è la prima causa genetica di morte nell’infanzia. Lo dimostra uno studio pubblicato su Frontiers in Molecular Neuroscience dal nostro gruppo di ricerca guidato da Alessandro Vercelli, in collaborazione con l’Istituto Mario Negri di Milano. Chiarire i meccanismi molecolari alla base della SMA può aprire la strada allo sviluppo di nuove terapie.