L. Musazzi, University of Milan

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Data dell'evento: 15/05/2015
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Friday, May 15th 2015 - h. 14:00
Seminar Room, NICO
Time-dependent structural, functional and behavioural changes induced by acute stress at excitatory synapses in prefrontal and frontal cortex
Laura Musazzi
Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission
Department of Pharmacological and Biomolecular Sciences, University of Milan
Stress deeply affects gene regulation, neurotransmission and synaptic morphology, and activate a stress response to restore homeostasis. However, when stress exposure is chronic, uncontrollable, or overwhelming, it represents a major risk factor for many diseases, including neuropsychiatric disorders.
Intriguingly, modifications of the glutamatergic system induced by stress in the prefrontal cortex seem to be biphasic. Indeed, while the fast response to stress suggests an enhancement in the number of excitatory synapses, synaptic transmission and working memory, long-term adaptive changes, including those consequent to chronic stress, induce opposite effects.
The identification of neural mechanisms underling resilience and vulnerability to stress is of crucial importance in the understanding of neuropsychiatric disorders pathophysiology and in the development of improved treatments.

Host: Alessandro Vercelli

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Agenda

12 gennaio 2018

NICO Progress Report

I nostri giovani ricercatori aggiornano i colleghi sulle loro ricerche. Appuntamento ogni due venerdì.

Ricerca

Neuroni "immaturi": ecco la riserva che può prevenire l'invecchiamento cerebrale

Il nostro gruppo di ricerca guidato da Luca Bonfanti ha individuato una riserva di neuroni “immaturi” in zone inedite del cervello: si aprono nuovi scenari per compensare la scarsa capacità del cervello di rigenerarsi. Lo studio è stato pubblicato sul Journal of Neuroscience di dicembre.

10 gennaio 2018