Friday, May 15th 2015
- h. 14:00
Seminar Room, NICO
Time-dependent structural, functional and behavioural changes induced by acute stress at excitatory synapses in prefrontal and frontal cortex
Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission
Department of Pharmacological and Biomolecular Sciences, University of Milan
Stress deeply affects gene regulation, neurotransmission and synaptic morphology, and activate a stress response to restore homeostasis. However, when stress exposure is chronic, uncontrollable, or overwhelming, it represents a major risk factor for many diseases, including neuropsychiatric disorders.
Intriguingly, modifications of the glutamatergic system induced by stress in the prefrontal cortex seem to be biphasic. Indeed, while the fast response to stress suggests an enhancement in the number of excitatory synapses, synaptic transmission and working memory, long-term adaptive changes, including those consequent to chronic stress, induce opposite effects.
The identification of neural mechanisms underling resilience and vulnerability to stress is of crucial importance in the understanding of neuropsychiatric disorders pathophysiology and in the development of improved treatments.
Host: Alessandro Vercelli
Events & Meetings
Our young researchers present their work to collegues. From January to December, every two weeks, on friday at 2:00 pm
Seminars Room, NICO
The main goal of the BraYn initiative is to organize a scientific conference involving different laboratories across Italy and Europe where young researchers, especially PhD students and junior postdocs, can share their knowledge, skills and ideas to establish new collaborations between different research groups.