Monday, 23th February - h 14:30
Seminars room, NICO
Molecular fine-tuning in the perineuronal nets orchestrate plasticity and repair in the CNS
John van Geest Centre for Brain Repair, University of Cambridge (UK)
PNNs are a layer of macromolecular complexes in which extracellular matrix molecules, polysaccharides (such as chondroitin sulphate proteoglycans and hyaluronan) and soluble proteins, form a compact layer of aggregates and anchor onto the neuronal surface. Using biochemical, cell biology, together with functional studies, we have established the core molecular and structural components of the PNNs and demonstrated that manipulation of PNNs effectively increases plasticity in the adult CNS.
Host: Daniela Carulli
Since 2001, this meeting represented an important event for basic and clinical researchers working on this emerging scientific topic. We will address state-of-the-art approaches in the field of steroids and nervous system, including behavior, epigenetics, genomic and non-genomic actions, the vitamin D, neurodegenerative and psychiatric disorders, and the interference among endocrine disruptors and steroid signaling.
Un malfunzionamento dei mitocondri, le centrali energetiche delle cellule, causa lo sviluppo della SCA28, una forma ereditaria di atassia. Dopo 10 anni di studi e grazie al sostegno di Fondazione Telethon, la scoperta del team di ricerca guidato dai proff. Alfredo Brusco e Filippo Tempia dell’Università di Torino e NICO. Lo studio pubblicato sulla prestigiosa rivista Neurobiology of Disease.