A. Carboni, University of Milan

Condividi su
Data dell'evento: 23/10/2015
milano_torino_2

Friday, 23th October 2015 - h 14:00
Seminars Room, NICO

Class 3 semaphorins in the control of GnRH neuron development and diseases
Anna Carboni
Dept. of Pharmacological and Biomolecular Sciences, University of Milan
GnRH secreting neurons are hypothalamic neuroendocrine cells that control reproductive axis. During development, they are thought to originate in the nasal placode and migrate associated with the vomeronasal axons to reach their final positions in the hypothalamus.

Developmental defects may be at the origin of genetic disorders such as Hypogonaditropic Hypogonadism (HH) and Kallmann syndrome (KS) whom mutated loci are largely unknown. By applying genetically modified mouse models, cellular models and mutational analysis we found that class 3 semaphorins play essential roles during different phases of GnRH neuron development and are implicated in the pathogenesis of some forms of HH and KS.

Ospite: Annalisa Buffo

Agenda

06 novembre 2018

ZEISS Academy Workshop – Microscopia Correlativa 3D

Le ultime novità nella Microscopia Correlativa Multi-modale. Registrazione obbligatoria.

16 febbraio 2019

Torino - 10th International Meeting STEROIDS and NERVOUS SYSTEM

Since 2001, this meeting represented an important event for basic and clinical researchers working on this emerging scientific topic. We will address state-of-the-art approaches in the field of steroids and nervous system, including behavior, epigenetics, genomic and non-genomic actions, the vitamin D, neurodegenerative and psychiatric disorders, and the interference among endocrine disruptors and steroid signaling.

Ricerca

Identificato un nuovo bersaglio per contrastare la SMA

L’inibizione della proteina JNK rallenta la progressione della malattia che colpisce i motoneuroni ed è la prima causa genetica di morte nell’infanzia. Lo dimostra uno studio pubblicato su Frontiers in Molecular Neuroscience dal nostro gruppo di ricerca guidato da Alessandro Vercelli, in collaborazione con l’Istituto Mario Negri di Milano. Chiarire i meccanismi molecolari alla base della SMA può aprire la strada allo sviluppo di nuove terapie.

24 ottobre 2018