Friday, 23th October 2015 - h 14:00
Seminars Room, NICO
Class 3 semaphorins in the control of GnRH neuron development and diseases
Dept. of Pharmacological and Biomolecular Sciences, University of Milan
GnRH secreting neurons are hypothalamic neuroendocrine cells that control reproductive axis. During development, they are thought to originate in the nasal placode and migrate associated with the vomeronasal axons to reach their final positions in the hypothalamus.
Developmental defects may be at the origin of genetic disorders such as Hypogonaditropic Hypogonadism (HH) and Kallmann syndrome (KS) whom mutated loci are largely unknown. By applying genetically modified mouse models, cellular models and mutational analysis we found that class 3 semaphorins play essential roles during different phases of GnRH neuron development and are implicated in the pathogenesis of some forms of HH and KS.
Ospite: Annalisa Buffo
Chiarire la complessità delle funzioni dei miRNA può permettere di modularli a fini terapeutici, ad esempio per stimolare la ricrescita assonale o per modulare la neuroinfiammazione nelle lesioni traumatiche. La review - a firma di Matilde Ghibaudi, Marina Boido e del nostro direttore Alessandro Vercelli - è scaricabile gratuitamente fino a dicembre.