Friday, 23th October 2015 - h 14:00
Seminars Room, NICO
Class 3 semaphorins in the control of GnRH neuron development and diseases
Dept. of Pharmacological and Biomolecular Sciences, University of Milan
GnRH secreting neurons are hypothalamic neuroendocrine cells that control reproductive axis. During development, they are thought to originate in the nasal placode and migrate associated with the vomeronasal axons to reach their final positions in the hypothalamus.
Developmental defects may be at the origin of genetic disorders such as Hypogonaditropic Hypogonadism (HH) and Kallmann syndrome (KS) whom mutated loci are largely unknown. By applying genetically modified mouse models, cellular models and mutational analysis we found that class 3 semaphorins play essential roles during different phases of GnRH neuron development and are implicated in the pathogenesis of some forms of HH and KS.
Ospite: Annalisa Buffo
Since 2001, this meeting represented an important event for basic and clinical researchers working on this emerging scientific topic. We will address state-of-the-art approaches in the field of steroids and nervous system, including behavior, epigenetics, genomic and non-genomic actions, the vitamin D, neurodegenerative and psychiatric disorders, and the interference among endocrine disruptors and steroid signaling.
Un malfunzionamento dei mitocondri, le centrali energetiche delle cellule, causa lo sviluppo della SCA28, una forma ereditaria di atassia. Dopo 10 anni di studi e grazie al sostegno di Fondazione Telethon, la scoperta del team di ricerca guidato dai proff. Alfredo Brusco e Filippo Tempia dell’Università di Torino e NICO. Lo studio pubblicato sulla prestigiosa rivista Neurobiology of Disease.