Friday, 23th October 2015 - h 14:00
Seminars Room, NICO
Class 3 semaphorins in the control of GnRH neuron development and diseases
Dept. of Pharmacological and Biomolecular Sciences, University of Milan
GnRH secreting neurons are hypothalamic neuroendocrine cells that control reproductive axis. During development, they are thought to originate in the nasal placode and migrate associated with the vomeronasal axons to reach their final positions in the hypothalamus.
Developmental defects may be at the origin of genetic disorders such as Hypogonaditropic Hypogonadism (HH) and Kallmann syndrome (KS) whom mutated loci are largely unknown. By applying genetically modified mouse models, cellular models and mutational analysis we found that class 3 semaphorins play essential roles during different phases of GnRH neuron development and are implicated in the pathogenesis of some forms of HH and KS.
Ospite: Annalisa Buffo
Events & Meetings
University of Turin, Italy
The Workshop is aimed at PhD students and young Postdocs with the goal to promote a thorough understanding of the functions of glial cells in health and disease. The program includes lectures on the newest conceptual advancements and methodological approaches in the study of glial cells in synaptic functions, development and CNS diseases.
Deadline for registration: December 23, 2019.