Physiology & Behavior - A. Rodriguez-Gomez, F. Filice, S. Gotti, G. Panzica

Condividi su
25/05/2014
Physiology & Behavior - A. Rodriguez-Gomez, F. Filice, S. Gotti, G. Panzica
S00319384

Physiology & Behavior, May 2014

Perinatal exposure to genistein affects the normal development of anxiety and aggressive behaviors and nitric oxide system in CD1 male mice.

Rodriguez-Gomez A.1, Filice F., Gotti S.1, Panzica G.1

Genistein is a phytoestrogen, particularly abundant in soybeans, that is able to bind estrogen receptors exerting both estrogenic and antiestrogenic activities. Genistein is largely present in the human diet even during pregnancy. Embryos and fetuses are therefore, commonly exposed to genistein during the development and after birth. In the present study, we used a murine model as a test end-point to investigate the effects of early exposure to genistein on adult male behavior and related neural circuits.

Exposure of dams to genistein (100?g/g of body weight) daily during late pregnancy and early lactation, produced in male offspring, when adults, significant changes in anxiety behavior and statistically significant variations in the number of neuronal nitric-oxide synthase positive cells in the amygdala. In conclusions, these data indicate that early exposure to phytoestrogens may induce life-long effects on the differentiation of brain structures and behaviors. [read more - PubMed.org]

1Department of Neuroscience, University of Torino; Neuroscience Institute Cavalieri-Ottolenghi (NICO)

Graphical abstract

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Agenda

26 febbraio 2020

GLIAL CELLS-NEURON CROSSTALK IN CNS HEALTH AND DISEASE

University of Turin, Italy  
The Workshop is aimed at PhD students and young Postdocs with the goal to promote a thorough understanding of the functions of glial cells in health and disease. The program includes lectures on the newest conceptual advancements and methodological approaches in the study of glial cells in synaptic functions, development and CNS diseases.

Deadline for registration: December 23, 2019.

Sportello LESIONI SPINALI

Paziente tetraplegico operato al CTO di Torino torna a usare le mani

Una notizia che abbiamo letto tutti di recente sui giornali. Noi del NICO abbiamo la fortuna di collaborare da anni con il dott. Bruno Battiston e il prof. Diego Garbossa - i chirurghi che hanno svolto l'operazione - e ci siamo fatti spiegare bene in cosa consiste l’intervento, quale era la situazione del paziente e quali saranno i possibili risultati. 
Tutto questo al di là delle semplificazioni e dei titoli roboanti dei giornali, comprensibilmente utilizzati per attirare l’attenzione dei lettori.

10 giugno 2019