Frontiers in Neuroscience - P. Peretto - E. Boda and A. Buffo

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09/05/2014
Frontiers in Neuroscience - P. Peretto - E. Boda and A. Buffo

9 May 2014

How neurogenesis finds its place in a hardwired sensory system

Livio Oboti1 and Paolo Peretto2

So far most studies on adult neurogenesis aimed to unravel mechanisms and molecules regulating the integration of newly generated neurons in the mature brain parenchyma. The exceedingly abundant amount of results that followed, rather than being beneficial in the perspective of brain repair, provided a clear evidence that adult neurogenesis constitutes a necessary feature to the correct functioning of the hosting brain regions. In particular, the rodent olfactory system represents a privileged model to study how neuronal plasticity and neurogenesis interact with sensory functions. Until recently, the vomeronasal system (VNS) has been commonly described as being specialized in the detection of innate chemosignals.

Accordingly, its circuitry has been considered necessarily stable, if not hard-wired, in order to allow stereotyped behavioral responses. However, both first and second order projections of the rodent VNS continuously change their synaptic connectivity due to ongoing postnatal and adult neurogenesis. How the functional integrity of a neuronal circuit is maintained while newborn neurons are continuously added—or lost—is a fundamental question for both basic and applied neuroscience. The VNS is proposed as an alternative model to answer such question. Hereby the underlying motivations will be reviewed. [read full article]

1Children's National Health System, Center for Neuroscience Research, Washington, DC, USA
2Department of Life Sciences and Systems Biology, Neuroscience Institute Cavalieri Ottolenghi, University of Torino, Orbassano, Italy

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23 May 2014

Beyond cell replacement: unresolved roles of NG2-expressing progenitors

Enrica Boda and Annalisa Buffo*

enrica_sito

NG2-expressing parenchymal precursors (NG2+p) serve as primary source of myelinating oligodendrocytes in both the developing and adultCentral Nervous System (CNS). However, their abundance, limited differentiation potential at adult stages along with stereotypic reaction to injury independent of the extent of myelin loss suggest that NG2+p exert functions additional to myelin production. In support of this view, NG2+p express a complex battery of molecules known to exert neuromodulatory and neuroprotective functions.

Further, they establish intimate physical associations with the other CNS cell types, receive functional synaptic contacts and possess ion channels apt to constantly sense the electrical activity of surrounding neurons. These latter features could endow NG2+p with the capability to affect neuronal functions with potential homeostatic outcomes. Here we summarize and discuss current evidence favoring the view that NG2+p can participate in circuit formation, modulate neuronal activity and survival in the healthy and injured CNS, and propose perspectives for studies that may complete our understanding of NG2+p roles in physiology and pathology. [read full article]

*Department of Neuroscience Rita Levi-Montalcini, Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Turin, Italy

Ricerca

Lesioni traumatiche: una review per chiarire la complessità delle funzioni dei miRNA

Chiarire la complessità delle funzioni dei miRNA può permettere di modularli a fini terapeutici, ad esempio per stimolare la ricrescita assonale o per modulare la neuroinfiammazione nelle lesioni traumatiche. La review - a firma di Matilde Ghibaudi, Marina Boido e del nostro direttore Alessandro Vercelli - è scaricabile gratuitamente fino a dicembre.

6 novembre 2017