Serena Quarta, Medical University Innsbruck

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Data dell'evento: 15/02/2018
seminars_2018

Thursday, 15th February – h. 14:00
Seminars Room, NICO

Dr. Serena Quarta
Medical University Innsbruck, Austria

The role of the inflammation mediators gp130 receptor and sphingosine-1-phosphate in peripheral neuronal regeneration

Neurons are able to change their signaling pathway and network in order to react to warning signals in pathological conditions. The inflammation mediators, theIL-6 signal transducer gp130 and thebioactive lipid sphingosine-1-phosphate (S1P) play a dual role, not only in neuronal excitability and pain sensitivity but also in neuron regeneration after injury. Lack of g130 causes delay in sensory recovery in vivo after crush injury and reduced skin reinnervation.

Moreover, gp130 is found to be a determining factor for the growth promoting action of NGF in adult sensory neurons. The sphingolipid S1P has alsoa critical role in fine-tuning axonal outgrowth in sensory neurons and regeneration of peripheral fibers. S1P can indeed activate differentially GCPRs supporting neurite elongation or retraction depending by the cell needs.Modulation of the above signaling pathways through genetic modifications or pharmacological tools canimprove pathological states.

Host: Ferdinando Di Cunto

Agenda

16 febbraio 2018

NICO Progress Report

I nostri giovani ricercatori aggiornano i colleghi sulle loro ricerche. Appuntamento ogni due venerdì.

Ricerca

Neuroni "immaturi": ecco la riserva che può prevenire l'invecchiamento cerebrale

Il nostro gruppo di ricerca guidato da Luca Bonfanti ha individuato una riserva di neuroni “immaturi” in zone inedite del cervello: si aprono nuovi scenari per compensare la scarsa capacità del cervello di rigenerarsi. Lo studio è stato pubblicato sul Journal of Neuroscience di dicembre.

10 gennaio 2018