Friday, April 17th 2015 - h. 14:00
Seminars Room, NICO
Extrinsic mechanisms regulate the GPR17 receptor during oligodendrocyte precursor cell maturation: implications for the development of new remyelinating strategies
Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission
Department of Pharmacological and Biomolecular Sciences, University of Milan
During oligodendrocyte precursor cell differentiation, defective control of the membrane receptor GPR17 has been suggested to block cell maturation and impair remyelination under demyelinating conditions.
Here, we show that the ubiquitin ligase Mdm2, known to be involved in ubiquitination/degradation of p53, regulates GPR17 responses at the cell membrane by intertwining mTOR with G-protein receptor kinase 2.
Host: Alessandro Vercelli
Since 2001, this meeting represented an important event for basic and clinical researchers working on this emerging scientific topic. We will address state-of-the-art approaches in the field of steroids and nervous system, including behavior, epigenetics, genomic and non-genomic actions, the vitamin D, neurodegenerative and psychiatric disorders, and the interference among endocrine disruptors and steroid signaling.
«Garantire un futuro migliore a chi soffre di malattie che conosciamo bene, come Alzheimer, Sclerosi Multipla e SMA». Il nostro amico Hervé Barmasse spiega perché è importante sostenere il lavoro dei nostri 70 ricercatori. Come? Con una piccola donazione o con il tuo 5xmille. Guarda il video!