Friday, March 27th 2015 - h. 14:00
Seminars Room, NICO
The influence of estradiol on microglia polarization
Department of Pharmacological and Biomolecular Sciences, University of Milan
The anti-inflammatory properties of estrogens in the CNS are under study in our laboratory since several years. Yet, we still lack a thorough understanding of the impact exerted by genetic sex, physiologically circulating estrogens, and the cessation of ovarian functions on microglia phenotype, with potential effects on neuroinflammation (NI) and the onset and progression of neurodegenerative diseases.
We investigated by means of high throughput RNA sequencing the distinctive genetic programs of microglia freshly isolated from the brain of males, intact cycling female mice and ovariectomized females (OVX), as a murine model for menopause. The analysis revealed a particular influence of genetic sex and ovarian hormones on the immune response-related pathways.
We integrated these genome-wide studies with in vitro studies on cellular models, and identified distinct molecular mechanisms underlying the action exerted by estrogen on the immune cell activation state. The presented data will show that peculiar differences exist among males and females that are dictated by genetic sex as well as estrogens and help providing the molecular basis for the gender related differences in the neurodegenerative diseases.
Host: Alessandro Vercelli
University of Turin, Italy
The Workshop is aimed at PhD students and young Postdocs with the goal to promote a thorough understanding of the functions of glial cells in health and disease. The program includes lectures on the newest conceptual advancements and methodological approaches in the study of glial cells in synaptic functions, development and CNS diseases.
Deadline for registration: December 23, 2019.
Sportello LESIONI SPINALI
Una notizia che abbiamo letto tutti di recente sui giornali. Noi del NICO abbiamo la fortuna di collaborare da anni con il dott. Bruno Battiston e il prof. Diego Garbossa - i chirurghi che hanno svolto l'operazione - e ci siamo fatti spiegare bene in cosa consiste l’intervento, quale era la situazione del paziente e quali saranno i possibili risultati.
Tutto questo al di là delle semplificazioni e dei titoli roboanti dei giornali, comprensibilmente utilizzati per attirare l’attenzione dei lettori.