Friday, March 27th 2015 - h. 14:00
Seminars Room, NICO
The influence of estradiol on microglia polarization
Department of Pharmacological and Biomolecular Sciences, University of Milan
The anti-inflammatory properties of estrogens in the CNS are under study in our laboratory since several years. Yet, we still lack a thorough understanding of the impact exerted by genetic sex, physiologically circulating estrogens, and the cessation of ovarian functions on microglia phenotype, with potential effects on neuroinflammation (NI) and the onset and progression of neurodegenerative diseases.
We investigated by means of high throughput RNA sequencing the distinctive genetic programs of microglia freshly isolated from the brain of males, intact cycling female mice and ovariectomized females (OVX), as a murine model for menopause. The analysis revealed a particular influence of genetic sex and ovarian hormones on the immune response-related pathways.
We integrated these genome-wide studies with in vitro studies on cellular models, and identified distinct molecular mechanisms underlying the action exerted by estrogen on the immune cell activation state. The presented data will show that peculiar differences exist among males and females that are dictated by genetic sex as well as estrogens and help providing the molecular basis for the gender related differences in the neurodegenerative diseases.
Host: Alessandro Vercelli
Since 2001, this meeting represented an important event for basic and clinical researchers working on this emerging scientific topic. We will address state-of-the-art approaches in the field of steroids and nervous system, including behavior, epigenetics, genomic and non-genomic actions, the vitamin D, neurodegenerative and psychiatric disorders, and the interference among endocrine disruptors and steroid signaling.
L’inibizione della proteina JNK rallenta la progressione della malattia che colpisce i motoneuroni ed è la prima causa genetica di morte nell’infanzia. Lo dimostra uno studio pubblicato su Frontiers in Molecular Neuroscience dal nostro gruppo di ricerca guidato da Alessandro Vercelli, in collaborazione con l’Istituto Mario Negri di Milano. Chiarire i meccanismi molecolari alla base della SMA può aprire la strada allo sviluppo di nuove terapie.