29.09 - F. Bussolino, Istituto di Candiolo IRCCS

Condividi su
Data dell'evento: 29/09/2014
seminars_2014

Lunedì 29 settembre - ore 14:00
Aula Seminari, NICO 

Transcription Factor EB and the development of cardiovascular system

Prof. Federico Bussolino
Istituto di Candiolo - IRCCS

TFBE belongs to the microphtalmia family of bHLH-leucine zipper transcription factors.
TFBE was originally described to be translocated in a juvenile subset of renal carcinomas and is implicated in the controls the autophagy-lysosomal pathway by recognizing a recurrent motif present in the promoter regions of more than 400 genes that participate to lysosome biogenesis (CLEAR network).

TFEB overexpression increases the number of lysosomes improving the capacity to degrade complex molecules by facilitating autophagosome assembly, in particular when cells are stressed by starvation and hypoxia. The functions of Tfeb are mainly regulated by mTOR comoplex1 (mTORc1. mTORc1-mediated Tfeb phosphorylation occurs at the lysosomal surface and enables Tfeb binding to 14-3-3 protein, which prevents nuclear import).

In this seminar I will discuss the recent data of my Lab illustrating the in vitro and in vivo activities of Tfeb in cardiovascular system.

Ospite: Alessandro Vercelli

download pdf

Agenda

16 febbraio 2019

Torino - 10th International Meeting STEROIDS and NERVOUS SYSTEM

Since 2001, this meeting represented an important event for basic and clinical researchers working on this emerging scientific topic. We will address state-of-the-art approaches in the field of steroids and nervous system, including behavior, epigenetics, genomic and non-genomic actions, the vitamin D, neurodegenerative and psychiatric disorders, and the interference among endocrine disruptors and steroid signaling.

Ricerca

Hervé Barmasse, l'alpinista "figlio del Cervino": perché sostenere i ricercatori del NICO

«Garantire un futuro migliore a chi soffre di malattie che conosciamo bene, come Alzheimer, Sclerosi Multipla e SMA». Il nostro amico Hervé Barmasse spiega perché è importante sostenere il lavoro dei nostri 70 ricercatori. Come? Con una piccola donazione o con il tuo 5xmille. Guarda il video!

11 aprile 2018