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Gruppo guidato da Carola Eva




Bertocchi I, Eltokhi A, Rozov A, Nguyễn Chi V, Jensen V, Bus T, Pawlak V, Serafino M, Sonntag H, Yang B, Burnashev N, Li SB, Obenhaus HA, Both M, Niewoehner B, Single FN, Briese M, Boerner T, Gass P, Rawlins JNP, Köhr G, Bannerman DM& Sprengel R.(2021) Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice. Commun Biol. Jan 8;4(1):59. doi: 10.1038/s42003-020-01538-4.


Bertocchi  I, Mele  P, Ferrero  G, Oberto  A, Carulli  D, Eva C (2020) NPY-Y1 receptor signaling controls spatial learning and perineuronal net expression. Neuropharmacology. Dec 4;184: doi:10.1016/j.neuropharm.2020.108425

Eva C, Oberto A, Longo A, Palanza P, Bertocchi I. (2020) Sex differences in behavioral and metabolic effects of gene inactivation: The neuropeptide Y and Y receptors in the brain. Neurosci Biobehav Rev. 2020 Oct 9. pii: S0149-7634(20)30577-7. doi: 10.1016/j.neubiorev.2020.09.020. [Epub ahead of print]

Ilaria Bertocchi, Alessandra Oberto, Angela Longo, Paola Palanza, Carola Eva (2020). Conditional inactivation of Npy1r gene in mice induces sex-related differences of metabolic and behavioral functions. Horm Behav 2020 Aug 13;125:104824. doi: 10.1016/j.yhbeh.2020.104824.

Bertocchi I, Foglietta F, Collotta D, Eva C, Brancaleone V, Thiemermann C, Collino M. (2020) The hidden role of NLRP3 inflammasome in obesity-related COVID-19 exacerbations: Lessons for drug repurposing. Br J Pharmacol. 177(21):4921-4930.

Mastrocola R, Collotta D, Gaudioso G, Le Berre M, Cento AS, Ferreira Alves G, Chiazza F, Verta R, Bertocchi I, Manig F, Hellwig M, Fava F, Cifani C, Aragno M, Henle T, Joshi L, Tuohy K, Collino M. (2020) Effects of Exogenous Dietary Advanced Glycation End Products on the Cross-Talk Mechanisms Linking Microbiota to Metabolic Inflammation. Nutrients. 12(9):2497.


Hasan MT. et al. Fear Memory Engram and its Plasticity in the Hypothalamic Oxytocin System. Neuron, DOI: 10.1016/j.neuron. 2019.04.029 (2019)

Acton D, Ren X, Di Costanzo S, Dalet A, Bourane S,  Bertocchi I, Eva C, Goulding M. Spinal NPY1R+ Neurons form an Essential Excitatory Pathway for Mechanical Itch. Cell Reports, Volume 28, Issue 3, 16 July 2019, Pages 625-639.e6


Longo A. et al. Conditional inactivation of Npy1r gene induces mice behavioural inflexibility and orbitofrontal cortex hyperactivity that are reversed by escitalopram. Neuropharmacology 2018 May 1;133:12-22. doi: 10.1016/j.neuropharm.2018.01.018. Epub 2018 Jan 17.


Rosario Statello et al. Reduced NPY Y1 receptor hippocampal expression and signs of decreased vagal modulation of heart rate in mice. PHYSIOLOGY & BEHAVIOR, vol. 172, p. 31-39, ISSN: 0031-9384, doi: 10.1016/j.physbeh.2016.07.017 (2017)

Nuzzo AM, Giuffrida D, Masturzo B, Mele P, Piccoli E, Eva C, Todros T, Rolfo A. (2017) Altered expression of G1/S phase cell cycle regulators in placental mesenchymal stromal cells derived from preeclamptic pregnancies with fetal-placental compromise. Cell Cycle. 16(2):200-212.


Mele P, Zammaretti F, Longo A, Panzica G, Oberto A, Eva C. (2016) Sex-dependent regulation of hypothalamic neuropeptide Y-Y1 receptor gene expression in leptin treated obese (ob/ob) or lean mice. Brain Res. 1649:102-9.

Bo E, Farinetti A, Marraudino M, Sterchele D, Eva C, Gotti S, Panzica G. (2016) Adult exposure to tributyltin affects hypothalamic neuropeptide Y, Y1 receptor distribution, and circulating leptin in mice. Andrology. 4(4):723-34.

Obenhaus HA, Rozov A, Bertocchi I, Tang W, Kirsch J, Betz H, Sprengel R. (2016). Causal Interrogation of Neuronal Networks and Behavior through Virally transduced Ivermectin Receptors. Front Mol Neurosci, 9:75


Longo A, Oberto A, Mele P, Mattiello L, Pisu MG, Palanza P, Serra M, Eva C. (2015) NPY-Y1 coexpressed with NPY-Y5 receptors modulate anxiety but not mild social stress response in mice. Genes Brain Behav. 14(7):534-42. doi: 10.1111/gbb.12232. Epub 2015 Aug 18.


Fontana R, Della Torre S, Meda C, Longo A, Eva C, Maggi A (2014). Estrogen replacement therapy regulation of energy metabolism in female mouse hypothalamus. Endocrinology, 155:2213-2221

Longo A, Mele P, Bertocchi I, Oberto A, Bachmann A, Bartolomucci A, Palanza P, Sprengel R, Eva C (2014). Conditional inactivation of Neuropeptide Y-Y1 receptors unravels the role of Y1 and Y5 receptors co-expressing neurons in anxiety. Biol Psych 76,840–849


Hasan MT. et al. Role of motor cortex NMDA receptors in learning-dependent synaptic plasticity of behaving mice. Nature Communications (2013). Article number: 2258 doi: 10.1038/ncomms3258 ISSN: 2041-1723