Group leader: Carola Eva
Hasan MT. et al. A Fear Memory Engram and its Plasticity in the Hypothalamic Oxytocin System. Neuron, DOI: 10.1016/j.neuron. 2019.04.029 (2019)
Acton D, Ren X, Di Costanzo S, Dalet A, Bourane S, Bertocchi I, Eva C, Goulding M. Spinal NPY1R+ Neurons form an Essential Excitatory Pathway for Mechanical Itch. Cell Reports, Volume 28, Issue 3, 16 July 2019, Pages 625-639.e6
Longo A. et al. Conditional inactivation of Npy1r gene induces mice behavioural inflexibility and orbitofrontal cortex hyperactivity that are reversed by escitalopram . Neuropharmacology 2018 May 1;133:12-22. doi: 10.1016/j.neuropharm.2018.01.018. Epub 2018 Jan 17.
Rosario Statello et al. Reduced NPY Y1 receptor hippocampal expression and signs of decreased vagal modulation of heart rate in mice. PHYSIOLOGY & BEHAVIOR, vol. 172, p. 31-39, ISSN: 0031-9384, doi: 10.1016/j.physbeh.2016.07.017 (2017)
Mele P, Zammaretti F, Longo A, Panzica G, Oberto A, Eva C. (2016) Sex-dependent regulation of hypothalamic neuropeptide Y-Y1 receptor gene expression in leptin treated obese (ob/ob) or lean mice. Brain Res. 1649:102-9.
Bo E, Farinetti A, Marraudino M, Sterchele D, Eva C, Gotti S, Panzica G. (2016) Adult exposure to tributyltin affects hypothalamic neuropeptide Y, Y1 receptor distribution, and circulating leptin in mice. Andrology. 4(4):723-34.
Obenhaus HA, Rozov A, Bertocchi I, Tang W, Kirsch J, Betz H, Sprengel R. (2016). Causal Interrogation of Neuronal Networks and Behavior through Virally transduced Ivermectin Receptors. Front Mol Neurosci, 9:75
Longo A, Oberto A, Mele P, Mattiello L, Pisu MG, Palanza P, Serra M, Eva C. (2015) NPY-Y1 coexpressed with NPY-Y5 receptors modulate anxiety but not mild social stress response in mice. Genes Brain Behav. 14(7):534-42. doi: 10.1111/gbb.12232. Epub 2015 Aug 18.
Fontana R, Della Torre S, Meda C, Longo A, Eva C, Maggi A (2014). Estrogen replacement therapy regulation of energy metabolism in female mouse hypothalamus. Endocrinology, 155:2213-2221
Longo A, Mele P, Bertocchi I, Oberto A, Bachmann A, Bartolomucci A, Palanza P, Sprengel R, Eva C (2014). Conditional inactivation of Neuropeptide Y-Y1 receptors unravels the role of Y1 and Y5 receptors co-expressing neurons in anxiety. Biol Psych 76,840–849
Hasan MT. et al. Role of motor cortex NMDA receptors in learning-dependent synaptic plasticity of behaving mice. Nature Communications (2013). Article number: 2258 doi: 10.1038/ncomms3258 ISSN: 2041-1723
Varesio L, Emionite, L, Puppo M, Astigiano S, Lavieri R, Resaz R, Pezzolo A, Bosco MC, Oberto A, Eva C, Chou JY, Barbieri O, Eva A. (2011) Treatment of newborn G6pc‐/‐ mice with bone marrow‐derived myelomonocytes induces liver repair. Journal of Hepatology
Bertocchi I, Oberto A, Longo A, Mele P, Sabetta M, Bartolomucci A, Palanza P, Sprengel R, Eva C. (2011). Regulatory functions of limbic Y1 receptors in body weight and anxiety uncovered by conditional knockout and maternal care. Proc Natl Acad Sci US A Pnas
Resaz R, Emionite L, Vanni C, Astigiano S, Puppo M, Lavieri R, Segalerba D,Pezzolo A, Bosco MC, Oberto A, Eva C, Chou JY, Varesio L, Barbieri O, Eva A (2011). Treatment of newborn G6pc(-/-) mice with bone marrow-derived myelomonocytes induces liver repair. J Hepatol 55:1263-71
Martini M, Sica M, Gotti S, Eva C, Panzica GC (2011). Effects of estrous cycle and sex on the expression of neuropeptide Y1 receptor in discrete hypothalamic and limbic nuclei of transgenic mice. Peptides 32:1330-4
Eva C, Mele P, Collura D, Nai A, Pisu MG, Serra M, Biggio G (2008) Modulation of neuropeptide Y and Y1 receptor expression in the amygdala by fluctuations in the brain content of neuroactive steroids during ethanol drinking discontinuation in Y1R/LacZ transgenic mice. J Neurochem 104:1043-1054.
Conti L, Regis G, Longo A, Bernabei P, Chiarle R, Giovarelli M, Novelli F (2007) In the absence of IGF-1 signaling, IFN-gamma suppresses human malignant T-cell growth. Blood 109:2496-2504.
Oberto A, Acquadro E, Bus T, Sprengel R, Eva C (2007) Expression patterns of promoters for NPY Y(1) and Y(5) receptors in Y(5)RitTA and Y(1)RVenus BAC-transgenic mice. Eur J Neurosci 26:155-170.
Zammaretti F, Panzica G, Eva C (2007) Sex-dependent regulation of hypothalamic neuropeptide Y-Y1 receptor gene expression in moderate/high fat, high-energy diet-fed mice. J Physiol 583:445-454.
Eva C, Oberto A, Mele P, Serra M, Biggio G (2006a) Role of brain neuroactive steroids in the functional interplay between the GABA(A) and the NPY-Y1 receptor mediated signals in the amygdala. Pharmacol Biochem Behav 84:568-580.
Eva C, Serra M, Mele P, Panzica G, Oberto A (2006b) Physiology and gene regulation of the brain NPY Y1 receptor. Front Neuroendocrinol 27:308-339.
Cope DW, Halbsguth C, Karayannis T, Wulff P, Ferraguti F, Hoeger H, Leppa E, Linden AM, Oberto A, Ogris W, Korpi ER, Sieghart W, Somogyi P, Wisden W, Capogna M (2005) Loss of zolpidem efficacy in the hippocampus of mice with the GABAA receptor gamma2 F77I point mutation. Eur J Neurosci 21:3002-3016.
Leppa E, Vekovischeva OY, Linden AM, Wulff P, Oberto A, Wisden W, Korpi ER (2005) Agonistic effects of the beta-carboline DMCM revealed in GABA(A) receptor gamma 2 subunit F77I point-mutated mice. Neuropharmacology 48:469-478.
Cope DW, Wulff P, Oberto A, Aller MI, Capogna M, Ferraguti F, Halbsguth C, Hoeger H, Jolin HE, Jones A, McKenzie AN, Ogris W, Poeltl A, Sinkkonen ST, Vekovischeva OY, Korpi ER, Sieghart W, Sigel E, Somogyi P, Wisden W (2004) Abolition of zolpidem sensitivity in mice with a point mutation in the GABAA receptor gamma2 subunit. Neuropharmacology 47:17-34.
Eva C, Mele P, Oberto A, Panzica G, Pisu MG, Serra M (2004) Neuroanatomical and pharmacological evidence for a functional interaction between GABAergic and NPY-Y1 transmission in the amygdala of Y1R/LacZ transgenic mice. Crit Rev Neurobiol 16:33-41.
Mele P, Oberto A, Serra M, Pisu MG, Floris I, Biggio G, Eva C (2004) Increased expression of the gene for the Y1 receptor of neuropeptide Y in the amygdala and paraventricular nucleus of Y1R/LacZ transgenic mice in response to restraint stress. J Neurochem 89:1471-1478.
Ogris W, Poltl A, Hauer B, Ernst M, Oberto A, Wulff P, Hoger H, Wisden W, Sieghart W (2004) Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit. Biochem Pharmacol 68:1621-1629.
Oberto A, Mele P, Zammaretti F, Panzica G, Eva C (2003) Evidence of altered neuropeptide Y content and neuropeptide Y1 receptor gene expression in the hypothalamus of pregnant transgenic mice. Endocrinology 144:4826-4830.
Oberto A, Serra M, Pisu MG, Biggio G, Eva C (2002) Changes in expression of the neuropeptide Y Y1 receptor gene in the medial amygdala of transgenic mice during pregnancy and after delivery. J Neurochem 82:1272-1281.
Rocca P, De Leo C, Eva C, Marchiaro L, Milani AM, Musso R, Ravizza L, Zanalda E, Bogetto F (2002) Decrease of the D4 dopamine receptor messenger RNA expression in lymphocytes from patients with major depression. Prog Neuropsychopharmacol Biol Psychiatry 26:1155-1160.
Ferrara G, Serra M, Zammaretti F, Pisu MG, Panzica GC, Biggio G, Eva C (2001) Increased expression of the neuropeptide Y receptor Y(1) gene in the medial amygdala of transgenic mice induced by long-term treatment with progesterone or allopregnanolone. J Neurochem 79:417-425.
Oberto A, Panzica GC, Altruda F, Eva C (2001) GABAergic and NPY-Y(1) network in the medial amygdala: a neuroanatomical basis for their functional interaction. Neuropharmacology 41:639-642.
Zammaretti F, Panzica G, Eva C (2001) Fasting, leptin treatment, and glucose administration differentially regulate Y(1) receptor gene expression in the hypothalamus of transgenic mice. Endocrinology 142:3774-3782.
Musso R, Maggi A, Eva C (2000) 17 beta-estradiol stimulates mouse neuropeptide Y-Y(1) receptor gene transcription by binding to estrogen receptor alpha in neuroblastoma cells. Neuroendocrinology 72:360-367.
Oberto A, Panzica G, Altruda F, Eva C (2000) Chronic modulation of the GABA(A) receptor complex regulates Y1 receptor gene expression in the medial amygdala of transgenic mice. Neuropharmacology 39:227-234.
Rocca P, Beoni AM, Eva C, Ferrero P, Maina G, Bogetto F, Ravizza L (2000) Lymphocyte peripheral benzodiazepine receptor mRNA decreases in obsessive-compulsive disorder. Eur Neuropsychopharmacol 10:337-340.