Neurogenesi embrionale

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Gruppo guidato da Ferdinando Di Cunto

Neurogenesi embrionale

Pubblicazioni

2020

Pallavicini G, Iegiani G, Berto GE, Calamia E, Trevisiol E, Veltri A, Allis S, Di Cunto F.  CITK Loss Inhibits Growth of Group 3 and Group 4 Medulloblastoma Cells and Sensitizes Them to DNA-Damaging Agents. Cancers, 12 (3) 2020 Feb 26  DOI: 10.3390/cancers12030542. PMID: 32111106

2019

Chiotto AMA, Migliorero M, Pallavicini G, Bianchi FT, Gai M, Di Cunto F, Berto GE. Neuronal Cell-Intrinsic Defects in Mouse Models of Down Syndrome. Front Neurosci. 2019 Oct 10;13:1081. doi: 10.3389/fnins.2019.01081. eCollection 2019.
PubMed PMID: 31649502; PubMed Central PMCID: PMC6795679.

Grasso S, Cangelosi D, Chapelle J, Alzona M, Centonze G, Lamolinara A, Salemme V, Angelini C, Morellato A, Saglietto A, Bianchi FT, Cabodi S, Salaroglio IC, Fusella F, Ognibene M, Iezzi M, Pezzolo A, Poli V, Di Cunto F, Eva A, Riganti C,
Varesio L, Turco E, Defilippi P. The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma. Cell Death Differ. 2019 Jul 8. doi: 10.1038/s41418-019-0386-6. [Epub ahead of print] Erratum in: Cell Death Differ. 2019 Sep 5; PubMed PMID: 31285546.

Pallavicini G, Berto GE, Di Cunto F. Precision Revisited: Targeting Microcephaly Kinases in Brain Tumors. Int J Mol Sci. 2019 Apr 28;20(9). pii:E2098. doi: 10.3390/ijms20092098. Review. PubMed PMID: 31035417; PubMed Central PMCID: PMC6539168.

Tran THY, Yang DW, Kim M, Lee DH, Gai M, Di Cunto F, Choi KW, Lim DS. Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif. J Mol Cell Biol. 2019 Mar 13. pii: mjz013.
doi: 10.1093/jmcb/mjz013. [Epub ahead of print] PubMed PMID: 30865227.

2018

Pallavicini G, Sgro F, Garello F, Falcone M, Bitonto V, Berto GE, Bianchi FT, Gai M, Chiotto AM, Filippi M, Cutrin JC, Ala U, Terreno E, Turco E and Di Cunto F. Inactivation of citron kinase inhibits medulloblastoma progression by inducing apoptosis and cell senescence. Cancer Res. 2018 Jun. doi: 10.1158/0008-5472.CAN-17-4060.

Dema A, Macaluso F, Sgrò F, Berto GE, Bianchi FT, Chiotto AA, Pallavicini G, Di Cunto F and Gai M. Citron kinase-dependent F-actin maintenance at midbody secondary ingression sites mediates abscission. J Cell Sci. 2018 Apr 2;131(8). doi: 10.1242/jcs.209080.

Canosa A, De Marco G, Lomartire A, Rinaudo MT, Di Cunto F, Turco E, Barberis M, Brunetti M, Casale F, Moglia C, Calvo A, Marklund SL, Andersen PM, Mora G, Chiò A. A novel p.Ser108LeufsTer15 SOD1 mutation leading to the formation of a premature stop codon in an apparently sporadic ALS patient: insights into the underlying pathomechanisms. Neurobiol Aging. 2018 Dec;72:189.e11-189.e17.

Bianchi FT, Berto GE, Di Cunto F. Impact of DNA repair and stability defects on cortical development.
Cell Mol Life Sci. 2018 Nov;75(21):3963-3976

Bandini C, Pupuleku A, Spaccarotella E, Pellegrino E, Wang R, Vitale N, Duval C, Cantarella D, Rinaldi A, Provero P, Di Cunto F, Medico E, Bertoni F, Inghirami G, Piva R. IRF4 Mediates the Oncogenic Effects of STAT3 in Anaplastic Large Cell Lymphomas. Cancers (Basel). 2018 Jan 18;10(1).

2017

Bianchi FT, Tocco C, Pallavicini G, Liu Y, Vernì F, Merigliano C, Bonaccorsi S, El-Assawy N, Priano L, Gai M, Berto GE, Chiotto AM, Sgrò F, Caramello A, Tasca L, Ala U, Neri F, Oliviero S, Mauro A, Geley S, Gatti M, Di Cunto F. Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly. Cell Rep. 2017 Feb 14;18(7):1674-1686. doi:10.1016/j.celrep.2017.01.054.

Gai M, Di Cunto F. Citron kinase in spindle orientation and primary microcephaly. Cell Cycle. 2017 Feb;16(3):245-246. doi:10.1080/15384101.2016.1252584.

Bianchi, F.T., Gai, M., Berto, G.E., and Di Cunto, F. (2017b). Of rings and spines: The multiple facets of Citron proteins in neural development. Small GTPases 1–9.

Bosia, C., Sgrò, F., Conti, L., Baldassi, C., Brusa, D., Cavallo, F., Cunto, F.D., Turco, E., Pagnani, A., and Zecchina, R. (2017). RNAs competing for microRNAs mutually influence their fluctuations in a highly non-linear microRNA-dependent manner in single cells. Genome Biol. 18, 37.

2016

El Ghouzzi, V, Bianchi, F.T., Molineris, I., Mounce, B.C., Berto, G.E., Rak, M., Lebon, S., Aubry, L., Tocco, C., Gai, M., Chiotto, A.M., Sgro, F., Pallavicini, G., Simon-Loriere, E., Passemard, S., Vignuzzi, M., Gressens, P. and Di Cunto, F. (2016) ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly. Cell Death Dis, 7, e2440.

Gai, M., Bianchi, F.T., Vagnoni, C., Verni, F., Bonaccorsi, S., Pasquero, S., Berto, G.E., Sgro, F., Chiotto, A.M., Annaratone, L., Sapino, A., Bergo, A., Landsberger, N., Bond, J., Huttner, W.B. and Di Cunto, F. (2016) ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules. EMBO Rep, 17, 1396-1409.

Harding, B.N., Moccia, A., Drunat, S., Soukarieh, O., Tubeuf, H., Chitty, L.S., Verloes, A., Gressens, P., El Ghouzzi, V., Joriot, S., Di Cunto, F., Martins, A., Passemard, S. and Bielas, S.L. (2016) Mutations in Citron Kinase Cause Recessive Microlissencephaly with Multinucleated Neurons. Am J Hum Genet, 99, 511-520.

Sgro, F., Bianchi, F.T., Falcone, M., Pallavicini, G., Gai, M., Chiotto, A.M., Berto, G.E., Turco, E., Chang, Y.J., Huttner, W.B. and Di Cunto, F. (2016) Tissue-specific control of midbody microtubule stability by Citron kinase through modulation of TUBB3 phosphorylation. Cell Death Differ, 23, 801-813.

2015

Bergo, A., Strollo, M., Gai, M., Barbiero, I., Stefanelli, G., Sertic, S., Cobolli Gigli, C., Di Cunto, F., Kilstrup-Nielsen, C. and Landsberger, N. (2015) Methyl-CpG binding protein 2 (MeCP2) localizes at the centrosome and is required for proper mitotic spindle organization. J Biol Chem, 290, 3223-3237.

2014

Berto, G.E., Iobbi, C., Camera, P., Scarpa, E., Iampietro, C., Bianchi, F., Gai, M., Sgro, F., Cristofani, F., Gartner, A., Dotti, C.G. and Di Cunto, F. (2014) The DCR protein TTC3 affects differentiation and Golgi compactness in neurons through specific actin-regulating pathways. PLoS One, 9, e93721.

Molineris, I., Ala, U., Provero, P. and Di Cunto, F. (2014) Drug repositioning for orphan genetic diseases through Conserved Anticoexpressed Gene Clusters (CAGCs). BMC Bioinformatics, 14, 288.

Repetto, D., Camera, P., Melani, R., Morello, N., Russo, I., Calcagno, E., Tomasoni, R., Bianchi, F., Berto, G., Giustetto, M., Berardi, N., Pizzorusso, T., Matteoli, M., Di Stefano, P., Missler, M., Turco, E., Di Cunto, F. and Defilippi, P. (2014) p140Cap regulates memory and synaptic plasticity through Src-mediated and citron-N-mediated actin reorganization. J Neurosci, 34, 1542-1553.