Motor Neuron Diseases: understanding the pathogenetic mechanisms to develop therapies

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Event date: from 06/11/2020 to 07/11/2020
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under the patronage of  SINS - Italian Society for Neuroscience

titolo PAGINA
The virtual conference will focus on motor neuron diseases which consist in a group of neurological pathologies affecting motor neurons and causing their progressive degeneration. In the proposed meeting we will focus on Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA).
The conference aims to unravel the cellular and molecular mechanisms involved in the pathogenesis and progression of these diseases: of note, several of such altered mechanisms are also shared by other neurodegenerative pathologies.
Finally we will also give an overview of the currently available therapies and of the other developing therapeutic strategies.

Organizers:  M. Boido  &  S. Stanga

For info, contact:  |  

Registration and abstract submission will be open until October 15 th 2020  

>>  go to the registration form
Credits (CFU) : 2 for attendance + 0.5 for poster presentation


DAY 1 - 6 th November 2020

9.00-9.15  Welcome by the Organizers
9.15-9.45  D. Rossi, ICS Maugeri, Pavia Motor neuron diseases: an overview of ALS and SMA

9.45-10.45   Session I - ALS disease mechanisms

9.45-10.00   V. Crippa, Univ. Milan Proteostasis in ALS
10.00-10.15  G. Nardo, Mario Negri Institute, Milan Immune response in the peripheral nervous system and skeletal muscles is pivotal to counteract ALS
10.15-10.30  M. Milanese, Univ. Genoa Modulating the reactive phenotype of astrocytes as a therapeutic approach in amyotrophic lateral sclerosis
10.30-10.45  C. Rouaux, Inserm, Strasbourg - Evaluation of the corticofugal hypothesis of ALS

10.45-11.15  Q&A Session I - Meet the speakers

11.15-11.30  Break

11.30-11.45  Zeiss talk

11.45-12.15   Session II - ALS therapeutic approaches

11.45-12.00  D. Ferrari, Univ. Milan Bicocca Human neural stem cells for experimental cell therapies approaches in ALS: a synopsis of the experience from preclinical and Phase I clinical trials
12.00-12.15  A. Calvo, Univ. Turin New therapeutic strategies for ALS

12.15-12.35  Q&A Session II - Meet the speakers

[12.35-13.30   Attendees One Slide Presentation (to be evaluated by the scientific committee) or Attendees Poster Presentations ]

DAY 2 - 7 th November 2020

9.00-9.45   Session III - SMA disease mechanisms

9.00-9.15  G. Viero, CNR Trento Translational defects by positional sequencing: the case of SMA
9.15-9.30  R. Soler, Univ. Lleida Using motor neurons and iPSCs cultures to understand intracellular mechanisms leading to motoneuron degeneration in Spinal Muscular Atrophy
9.30-9.45  E. Di Schiavi, CNR Naples Use of C. elegans as experimental model to study SMA disease mechanisms

9.45-10.15   Session IV – SMA therapeutic approaches

9.45-10.00     T. Mongini, Univ. Turin - The new era of SMA therapy: results from real world experience and ongoing clinical trials
10.00-10.15  P. Konieczny, Univ. Valencia From flies to mice: evaluation of combinatorial therapy for SMA

10.15-10.45  Q&A Sessions III-IV - Meet the speakers

10.45-11.00  Break

11.00-12.30   Attendees Poster Presentations (to be evaluated by the scientific committee)

12.30-12.45  Media Lab System talk

12.45-13.00   Awards ceremony (Best One Slide/Poster Presentation)

13.00  Closing remarks & Goodbye to the next edition 2021!


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