Giovedì 12 giugno - ore 14,00
Aula Seminari, NICO
Nanotools for Neuroscience
Carlo Ricciardi , Emiliano Descrovi , Fabrizio Pirri
DISAT – Politecnico di Torino; IIT@POLITO - Istituto Italiano di Tecnologia
In the last years, remarkable progress has been made in developing novel materials and tools at the micro/nanoscale that have opened up new possibilities across science, engineering, and medicine. Some progress has already been made toward addressing problems in neuroscience via nanotechnology, such as nanoscale probes for electrophysiology or nanoparticles for enhanced imaging.
This talk will mainly focus on our recent developments in the field of nanobiosensing: mechanical (cantilever) and optical (photonic-crystal) biosensors, as well as spectroscopic tools (Surface Enhanced Raman Spectroscopy), will be introduced and described [1-3]. Real-time detection of low concentration of biomolecules will be shown.
Finally, we'll discuss some new research activities that we believe will have a deep impact in neuroscience: memristive devices to emulate (and possibly tune) synaptic plasticity in artificial (and possibly hybrid) networks , and light pattern generation for neuronal imaging and excitation .
Ospite: Alessandro Vercelli
1. C. Ricciardi et al. (2010) Development of microcantilever based biosensor array to detect Angiopoietin-1, a marker of tumor angiogenesis. In: BIOSENSORS & BIOELECTRONICS, vol. 25, pp. 1193-1198.
2. P. Rivolo et al. (2012) Real time secondary antibody detection by means of silicon-based multilayers sustaining Bloch surface waves. In: SENSORS AND ACTUATORS B, vol. 161, pp. 1046-1052.
3. A. Virga et al (2013) Silver nanoparticles on porous silicon: Approaching single molecule detection in resonant SERS regime. In: JOURNAL OF PHYSICAL CHEMISTRY C, vol 17, pp. 20139-20145.
4. F. Alibart et al. (2013) Pattern classification by memristive crossbar circuits using ex situ and in situ training. In: NATURE COMMUNICATIONS, 4:2072 doi: 10.1038/ncomms3072
5. I. Reutsky-Gefen et al (2013) Holographic optogenetic stimulation of patterned neuronal activity for vision restoration. In NATURE COMMUNICATIONS, 4:1509 doi: 10.1038/ncomms2500