2021
Eriola Hoxha, Ilaria Balbo, Roberta Parolisi, Matteo Audano, Francesca Montarolo, Francesco Ravera, Michela Guglielmotto, Luisa Muratori, Stefania Raimondo, Eleonora Di Gregorio, Annalisa Buffo, Alfredo Brusco, Barbara Borroni, Nico Mitro, Donatella Caruso, Filippo Tempia (2021) Elovl5 is required for proper action potential conduction along peripheral myelinated fibers. Glia. 17 June 2021 https://doi.org/10.1002/glia.24048
Tamagno E, Guglielmotto M. ESTROGENS STILL REPRESENT AN ATTRACTIVE THERAPEUTIC APPROACH FOR ALZHEIMER'S DISEASE. Neural Regeneration Research 2021, 16 in press
2020
Guglielmotto M, Manassero G, Vasciaveo V, Venezia M, Tabaton M, Tamagno E. Estrogens Inhibit Amyloid-β-Mediated Paired Helical Filament-Like Conformation of Tau Through Antioxidant Activity and miRNA 218 Regulation in hTau Mice. J Alzheimers Dis. 2020;77(3):1339-1351. doi: 10.3233/JAD-200707.PMID: 32804095
2019
Guglielmotto M, Repetto IE, Monteleone D, Vasciaveo V, Franchino C, Rinaldi S, Tabaton M, Tamagno E. (2019) Stroke and Amyloid-β Downregulate TREM-2 and Uch-L1 Expression that Synergistically Promote the Inflammatory Response. J Alzheimers Dis.71:907-920.
2018
Tamagno E, Guglielmotto M, Monteleone D, Manassero G, Vasciaveo V, Tabaton M. The Unexpected Role of Aβ1-42 Monomers in the Pathogenesis of Alzheimer's Disease. J Alzheimers Dis. 2018;62(3):1241-1245.
Testa G, Staurenghi E, Giannelli S, Gargiulo S, Guglielmotto M, Tabaton M, Tamagno E, Gamba P, Leonarduzzi G. A silver lining for 24-hydroxycholesterol in Alzheimer's disease: The involvement of the neuroprotective enzyme sirtuin 1. Redox Biol. 2018 17:423-431.
2017
Piras A, Schiaffino L, Boido M, Valsecchi V, Guglielmotto M, De Amicis E, Puyal J, Garcera A, Tamagno E, Soler RM, Vercelli A. Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy. Cell Death Dis. 2017 Dec 20;8(12):3223.
Manassero, G., Guglielmotto, M., Monteleone, D., Vasciaveo, V., Butenko, O., Tamagno, E., Arancio, O., Tabaton, M.. (2017). Dual Mechanism of Toxicity for Extracellular Injection of Tau Oligomers versus Monomers in Human Tau Mice. J Alzheimers Dis., 59(2):743-51.
Guglielmotto, M., Monteleone, D., Vasciaveo, V., Repetto, I.E., Manassero, G., Tabaton, M., Tamagno, E. (2017). The Decrease of Uch-L1 Activity Is a Common Mechanism Responsible for Aβ 42 Accumulation in Alzheimer's and Vascular Disease. Front Aging Neurosci., 9:320.
Tamagno, E., Guglielmotto, M., Monteleone, D., Manassero, G., Vasciaveo, V., Tabaton, M (2017). The Unexpected Role of Aβ1-42 Monomers in the Pathogenesis of Alzheimer's Disease. J Alzheimers Dis. 2017 Oct 30.
2016
Manassero G, Guglielmotto M, Zamfir R, Borghi R, Colombo L, Salmona M, Perry G, Odetti P, Arancio O, Tamagno E, Tabaton M. Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein. Aging Cell. 2016 Oct;15(5):914-23.
Guglielmotto M, Reineri S, Iannello A, Ferrero G, Vanzan L, Miano V, Ricci L, Tamagno E, De Bortoli M, Cutrupi S. E2 Regulates Epigenetic Signature on Neuroglobin Enhancer-Promoter in Neuronal Cells. Front Cell Neurosci. 2016 Jun 1;10:147.
Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222.
2014
Gamba P, Guglielmotto M, Testa G, Monteleone D, Zerbinati C, Gargiulo S, Biasi F, Iuliano L, Giaccone G, Mauro A, Poli G, Tamagno E, Leonarduzzi G (2014). Up- regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine. Aging Cell 13:561-72
Guglielmotto M, Monteleone D, Piras A, Valsecchi V, Tropiano M, Ariano S, Fornaro M, Vercelli A, Puyal J, Arancio O, Tabaton M, Tamagno E (2014). Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis. Autophagy 10:1827-43
2012
Guglielmotto M, Monteleone D, Boido M, Piras A, Giliberto L, Borghi R, Vercelli A, Fornaro M, Tabaton M, Tamagno E. (2012) Aβ1-42-mediated down-regulation of Uch-L1 is dependent on NF-κB activation and impaired BACE1 lysosomal degradation. Aging Cell. 11:834-844.
Guglielmotto M, Aragno M, Tamagno E, Vercellinatto I, Visentin S, Medana C, Catalano MG, Smith MA, Perry G, Danni O, Boccuzzi G, Tabaton M. (2012) AGEs/RAGE complex upregulates BACE1 via NF-β pathway activation. Neurobiol Aging 33:196.e13-27.
Piccini A, Borghi R, Guglielmotto M, Tamagno E, Cirmena G, Garuti A, Pollero V, Cammarata S, Fornaro M, Messa M, Colombo L, Salmona M, Perry G, Tabaton M. (2012) β-amyloid 1-42 induces physiological transcriptional regulation of BACE1.J Neurochem 122:1023-1031.
Tamagno E., Guglielmotto M., Monteleone D., Tabaton M. (2012) Amyloid-β production: major link between oxidative stress and BACE1. Neurotox Res 22:208-219.
2011
Gamba P., Leonarduzzi G., Tamagno E., Guglielmotto M., Testa G., Sottero B., Gargiulo S., Biasi F., Mauro A., Viña J., Poli G. (2011) Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. Aging Cell 10:403-417.
Guglielmotto M., Monteleone D., Giliberto L., Fornaro M., Borghi R., Tamagno E., Tabaton M. (2011) Amyloid-β activates the expression of BACE1 through the JNK pathway. J Alzheimers Dis 27:71-83.
Tamagno E, Guglielmotto M, Monteleone D, Tabaton M. Amyloid-β Production: Major Link Between Oxidative Stress and BACE1. Neurotox Res 2011 Oct 15. [Epub ahead of print] PubMed PMID:22002808
Mastrocola R, Guglielmotto M, Medana C, Catalano MG, Cutrupi S, Borghi R, Tamagno E, Boccuzzi G, Aragno M (2011). Dysregulation of SREBP2 induces BACE1 expression. Neurobiol Dis 44:116-24
Novo E, Busletta C, Bonzo LV, Povero D, Paternostro C, Mareschi K, Ferrero I, David E, Bertolani C, Caligiuri A, Cannito S, Tamagno E, Compagnone A, Colombatto S, Marra F, Fagioli F, Pinzani M, Parola M (2011). Intracellular reactive oxygen species are required for directional migration of resident and bone marrow-derived hepatic pro-fibrogenic cells. J Hepatol 54:964-74
Before 2010
Giliberto L., Borghi R., Piccini A., Mangerini R., Sorbi S., Cirmena G., Garuti A., Ghetti B., Tagliavini F., Mughal M.R., Mattson M.P., Zhu X., Wang X., Guglielmotto M., Tamagno E., Tabaton M. (2009) Mutant presenilin 1 increases the expression and activity of BACE1. J Biol Chem 284:9027-9038.
Guglielmotto M., Aragno M., Autelli R., Giliberto L., Novo E., Colombatto S., Danni O., Parola M., Smith M.A., Perry G., Tamagno E., Tabaton M. (2009) The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role ofoxidative stress and HIF1alpha. J Neurochem. 108:1045-1056.
Tamagno E., Guglielmotto M., Giliberto L., Vitali A., Borghi R., Autelli R., Danni O., Tabaton M. (2009) JNK and ERK1/2 pathways have a dual opposite effect on the expression of BACE1. Neurobiol Aging 30:1563-1573.
