Invecchiamento e malattia di Alzheimer

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Gruppo guidato da Elena Tamagno

Invecchiamento e malattia di Alzheimer

PUBBLICAZIONI

2021

Eriola Hoxha, Ilaria Balbo, Roberta Parolisi, Matteo Audano, Francesca Montarolo, Francesco Ravera, Michela Guglielmotto, Luisa Muratori, Stefania Raimondo, Eleonora Di Gregorio, Annalisa Buffo, Alfredo Brusco, Barbara Borroni, Nico Mitro, Donatella Caruso, Filippo Tempia (2021) Elovl5 is required for proper action potential conduction along peripheral myelinated fibers. Glia. 17 June 2021 https://doi.org/10.1002/glia.24048 

Tamagno E, Guglielmotto M. ESTROGENS  STILL REPRESENT AN ATTRACTIVE THERAPEUTIC APPROACH FOR ALZHEIMER'S DISEASE. Neural Regeneration Research 2021, 16 in press

2020

Guglielmotto M, Manassero G, Vasciaveo V, Venezia M, Tabaton M, Tamagno E. Estrogens Inhibit Amyloid-β-Mediated Paired Helical Filament-Like Conformation of Tau Through Antioxidant Activity and miRNA 218 Regulation in hTau Mice. J Alzheimers Dis. 2020;77(3):1339-1351. doi: 10.3233/JAD-200707.PMID: 32804095

2019

Guglielmotto M, Repetto IE, Monteleone D, Vasciaveo V, Franchino C, Rinaldi S, Tabaton M, Tamagno E. (2019)  Stroke and Amyloid-β Downregulate TREM-2 and Uch-L1 Expression that Synergistically Promote the Inflammatory Response. J Alzheimers Dis.71:907-920.

2018

Tamagno E, Guglielmotto M, Monteleone D, Manassero G, Vasciaveo V, Tabaton M. The Unexpected Role of Aβ1-42 Monomers in the Pathogenesis of Alzheimer's Disease. J Alzheimers Dis. 2018;62(3):1241-1245.

Testa G, Staurenghi E, Giannelli S, Gargiulo S, Guglielmotto M, Tabaton M, Tamagno E, Gamba P, Leonarduzzi G. A silver lining for 24-hydroxycholesterol in Alzheimer's disease: The involvement of the neuroprotective enzyme sirtuin 1. Redox Biol. 2018 17:423-431.

2017

Piras A, Schiaffino L, Boido M, Valsecchi V, Guglielmotto M, De Amicis E, Puyal J, Garcera A, Tamagno E, Soler RM, Vercelli A. Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy. Cell Death Dis. 2017 Dec 20;8(12):3223.

Manassero, G., Guglielmotto, M., Monteleone, D., Vasciaveo, V., Butenko, O., Tamagno, E., Arancio, O., Tabaton, M.. (2017). Dual Mechanism of Toxicity for Extracellular Injection of Tau Oligomers versus Monomers in Human Tau Mice. J Alzheimers Dis., 59(2):743-51.

Guglielmotto, M., Monteleone, D., Vasciaveo, V., Repetto, I.E., Manassero, G., Tabaton, M., Tamagno, E. (2017). The Decrease of Uch-L1 Activity Is a Common Mechanism Responsible for Aβ 42 Accumulation in Alzheimer's and Vascular Disease. Front Aging Neurosci., 9:320.

Tamagno, E., Guglielmotto, M., Monteleone, D., Manassero, G., Vasciaveo, V., Tabaton, M (2017). The Unexpected Role of Aβ1-42 Monomers in the Pathogenesis of Alzheimer's Disease. J Alzheimers Dis. 2017 Oct 30.

2016

Manassero G, Guglielmotto M, Zamfir R, Borghi R, Colombo L, Salmona M, Perry G, Odetti P, Arancio O, Tamagno E, Tabaton M. Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein. Aging Cell. 2016 Oct;15(5):914-23.

Guglielmotto M, Reineri S, Iannello A, Ferrero G, Vanzan L, Miano V, Ricci L, Tamagno E, De Bortoli M, Cutrupi S. E2 Regulates Epigenetic Signature on Neuroglobin Enhancer-Promoter in Neuronal Cells. Front Cell Neurosci. 2016 Jun 1;10:147.

Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222.