Physiopathology of neural stem cells

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Group leader:  Annalisa Buffo 

Physiopathology of neural stem cells
annalisa buffo

Annalisa Buffo

Associate Professor of Physiology

Contacts:

Tel    +39 011 670 6614
Fax   +39 011 670 6621
e-mail:  annalisa.buffo@unito.it

Born in Turin on 25.12.1967 - Italian.
1991. Doctor in Biological Sciences summa cum laude, University of Turin
1992-1993. Post-lauream apprenticeship at the II Neurological Clinic, Faculty of Medicine, University of Turin
1992-1998 Research fellow, University of Turin
1994. Professional certificate for Biologists, University of Turin
1998 Research Doctorate in Neurological Sciences, Ministry of Education and Science, Rome
1994-1999 Short research stays at the Rudolf Magnus Institute, University of Utrecht, Netherlands Institute for Brain Research, Amsterdam and University of Tuebingen
1998-2000 Postdoctoral fellow, Department of Physiology, University of Turin
2001-present Tenured Assistant Professor of Physiology (BIO/09), University of Turin
2004-2005 Visiting Researcher at the Helmholtz Zentrum (GSF, now Deutsches Forschungszentrum für Gesundheit und Umwelt, GmbH) and Ludwig Maximilans University, Munich, Germany

Research interests
Our research focuses on the role of glia and progenitor cells in brain plasticity and repair, and on the implementation of cell replacement approaches and/or training protocols to promote functional recovery in CNS diseases. We believe that specific issues regarding glia and neural progenitors are particularly promising to unveil new keys to the understanding of physiology, disease and repair.
We therefore investigate: (i) cellular and molecular mechanisms of astroglial heterogeneity and plasticity; (ii) physiopathology of oligodendrocyte progenitor cells; iii) therapeutic approaches for neurodegenerative diaseses based on cell replacement and training; main model systems are the cerebellum, the neocortex and the striatum of rodents.

>   Curriculum Vitae

Publications:

>   Publicationslist.org

>   PubMed.gov

> ORCID

S&P BRAIN
Services and Products for preclinical proof of concepts

Our spinoff provides scientific expertise, animal models, equipment and facilities to pharmaceutical, biotechnology, and medical device Companies and to Research Centers for proof–of-concept or pilot in vivo studies.

News

Multiple origins and modularity in the spatiotemporal emergence of cerebellar astrocyte heterogeneity

Plos Biology , 27 September 2018
V Cerrato, E Parmigiani, M Figueres-Oñate, M Betizeau, J Aprato, I Nanavaty, P Berchialla, F Luzzati, C de’Sperati, L Lopez-Mascaraque, A Buffo

11 October 2018

Control of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG Interaction

Developmental Cell , September 2017
Anissa Kempf, Enrica Boda, Jessica C.F. Kwok, Rafael Fritz, Valentina Grande, Andrea M. Kaelin, Zorica Ristic, Andre Schmandke, Antonio Schmandke, Bjoern Tews, James W. Fawcett, Olivier Pertz, Annalisa Buffo and Martin E. Schwab

10 October 2017

Preventive motor training but not progenitor grafting ameliorates cerebellar ataxia and deregulated autophagy in tambaleante mice.

Neurobiology of Disease , February 2017
Fucà E, Guglielmotto M, Boda E, Rossi F †, Leto K, Buffo A

10 March 2017

Transferrin Receptor 2 Dependent Alterations of Brain Iron Metabolism Affect Anxiety Circuits in the Mouse.

Scientific Reports
 Pellegrino RM, Boda E, Montarolo F, Boero M, Mezzanotte M, Saglio G, Buffo A, Roetto A

22 August 2016