A. Poletti, University of Milan

Share on
Event date: 10/09/2015
milano_torino_2

Friday, 11th September 2015 - h 14:00
Seminars Room, NICO

The protein quality control system in motoneuron diseases
Angelo Poletti
Dipartimento di Scienze Farmacologiche e Biomolecolari Università di Milano

Motor neuron diseases, like spinobulbar muscular atrophy (SBMA) and amyotrophic lateral sclerosis (ALS) are characterized by the presence of inclusions or aggregates of proteinaceous materials. This is due to the generation of aberrant conformations (misfolding) of the proteins responsible for the diseases.

In neuronal cells, the protein quality control (PQC) system may be insufficient to correctly remove the misfolded proteins.
The PQC system requires the activities of efficient chaperones and of the degradative systems ubiquitin-proteasome (UPS) and autophagy. Our approaches are to better characterize the role of the PQC in motoneuron diseases and to find possible ways to boost the PQC activity in order to prevent the damages induced by misfolded proteins to neurons.

Ospite:  Alessandro Vercelli

Events & Meetings

26 february 2020

GLIAL CELLS-NEURON CROSSTALK IN CNS HEALTH AND DISEASE

University of Turin, Italy   
The Workshop is aimed at PhD students and young Postdocs with the goal to promote a thorough understanding of the functions of glial cells in health and disease. The program includes lectures on the newest conceptual advancements and methodological approaches in the study of glial cells in synaptic functions, development and CNS diseases.

Deadline for registration: December 23, 2019.