Nerve regeneration

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Acting Group leader:  Stefania Raimondo (Stefano Geuna, Rector of the University of Turin)

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Publications

2019

G Gambarotta, S Raimondo, E Udina, J.B. Phillips and K Haastert-Talini.  Editorial: Peripheral Nerve Regeneration.  Front. Cell. Neurosci., 15 October 2019 | https://doi.org/10.3389/fncel.2019.00464

Alessandrino A, Fregnan F, Biagiotti M, Muratori L, Bassani GA, Ronchi G, Vincoli V, Pierimarchi P, Geuna S, Freddi G.  SilkBridge™: a novel biomimetic and biocompatible silk-based nerve conduit.  Biomater Sci. 2019 Oct 1;7(10):4112-4130. doi: 10.1039/c9bm00783k. Epub 2019 Jul 30. PubMed PMID: 31359013.

Colonna MR, Fazio A, Costa AL, Galletti F, Lo Giudice R, Galletti B, Galletti C, Lo Giudice G, Dell'Aversana Orabona G, Papalia I, Ronchi G, Geuna S.  The Use of a Hypoallergenic Dermal Matrix for Wrapping in Peripheral Nerve Lesions Regeneration: Functional and Quantitative Morphological Analysis in an Experimental Animal Model .  Biomed Res Int. 2019 Jun 17;2019:4750624. doi: 10.1155/2019/4750624. eCollection 2019. PubMed PMID: 31317030; PubMed Central PMCID: PMC6601684.

Ronchi G, Morano M, Fregnan F, Pugliese P, Crosio A, Tos P, Geuna S, Haastert-Talini K, Gambarotta G.  The Median Nerve Injury Model in Pre-clinical Research - A Critical Review on Benefits and Limitations.  Front Cell Neurosci. 2019 Jun 28;13:288. doi: 10.3389/fncel.2019.00288. eCollection 2019. Review. PubMed PMID: 31316355; PubMed Central PMCID: PMC6609919.

Jaminet P, Schäufele M, Mager A, Fornaro M, Ronchi G, Geuna S, Schaller HE, Rosenberger P, Köhler D.  Expression patterns and functional evaluation of RGMa during the early phase of peripheral nerve regeneration using the mouse median nerve model.  Restor Neurol Neurosci. 2019;37(3):265-272. doi: 10.3233/RNN-190913. PubMed PMID: 31177252.

Muratori L, Fregnan F, Ronchi G, Haastert-Talini K, Metzen J, Bertolo R, Porpiglia F, Geuna S.  New basic insights on the potential of a chitosan-based medical device for improving functional recovery after radical prostatectomy.  BJU Int. 2019 May 28. doi: 10.1111/bju.14834. [Epub ahead of print] PubMed PMID: 31134718.

Crosio A, Fornasari BE, Gambarotta G, Geuna S, Raimondo S, Battiston B, Tos P, Ronchi G.  Chitosan tubes enriched with fresh skeletal muscle fibers for delayed repair of peripheral nerve defects.  Neural Regen Res. 2019 Jun;14(6):1079-1084. doi: 10.4103/1673-5374.250628. PubMed PMID: 30762022; PubMed Central PMCID: PMC6404480.

Diogo CC, da Costa LM, Pereira JE, Filipe V, Couto PA, Geuna S, Armada-da-Silva PA, Maurício AC, Varejão ASP.  Kinematic and kinetic gait analysis to evaluate functional recovery in thoracic spinal cord injured rats.  Neurosci Biobehav Rev. 2019 Mar;98:18-28. doi: 10.1016/j.neubiorev.2018.12.027. Epub 2019 Jan 3. Review. PubMed PMID: 30611796.

Colonna MR, Pino D, Battiston B, d'Alcontres FS, Natsis K, Bassetto F, Papadopulos NA, Tiengo C, Geuna S.  Distal nerve transfer from the median nerve lumbrical fibers to the distal ulnar nerve motor branches in the palm: An anatomical cadaveric study.  Microsurgery. 2019 Jul;39(5):434-440. doi: 10.1002/micr.30402. Epub 2018 Dec 17. PubMed PMID: 30556926.

Mancini C, Hoxha E, Iommarini L, Brussino A, Richter U, Montarolo F, Cagnoli C, Parolisi R, Gondor Morosini DI, Nicolò V, Maltecca F, Muratori L, Ronchi G, Geuna S, Arnaboldi F, Donetti E, Giorgio E, Cavalieri S, Di Gregorio E, Pozzi E, Ferrero M, Riberi E, Casari G, Altruda F, Turco E, Gasparre G, Battersby BJ,Porcelli AM, Ferrero E, Brusco A, Tempia F.  Mice harbouring a SCA28 patient mutation in AFG3L2 develop late-onset ataxia associated with enhanced mitochondrial proteotoxicity.  Neurobiol Dis. 2019 Apr;124:14-28. doi: 10.1016/j.nbd.2018.10.018. Epub 2018 Oct 30. PubMed PMID: 30389403.

Gambarotta G, Raimondo S, Udina E, Phillips JB, Haastert-Talini K.  Editorial: Peripheral Nerve Regeneration.  Front Cell Neurosci. 2019 Oct 15;13:464. doi:10.3389/fncel.2019.00464. eCollection 2019. PubMed PMID: 31680873; PubMed Central PMCID: PMC6803521.

Gonçalves NP, Mohseni S, El Soury M, Ulrichsen M, Richner M, Xiao J, Wood RJ, Andersen OM, Coulson EJ, Raimondo S, Murray SS, Vægter CB.  Peripheral Nerve Regeneration Is Independent From Schwann Cell p75(NTR) Expression.  Front Cell Neurosci. 2019 May 29;13:235. doi: 10.3389/fncel.2019.00235. eCollection 2019. PubMed PMID: 31191256; PubMed Central PMCID: PMC6548843.

2018

Costa D, Diogo CC, Costa LMD, Pereira JE, Filipe V, Couto PA, Geuna S, Armada-Da-Silva PA, Maurício AC, Varejão ASP.  Kinematic patterns for hindlimb obstacle avoidance during sheep locomotion.   Neurol Res. 2018 Aug 14:1-9. doi:10.1080/01616412.2018.1505068. PubMed PMID: 30106355.

Russo I, Femminò S, Barale C, Tullio F, Geuna S, Cavalot F, Pagliaro P, Penna C.  Cardioprotective Properties of Human Platelets Are Lost in Uncontrolled Diabetes Mellitus: A Study in Isolated Rat Hearts.  Front Physiol. 2018 Jul 10;9:875. doi: 10.3389/fphys.2018.00875. eCollection 2018. PubMed PMID: 30042694; PubMed Central PMCID: PMC6048273.

Geuna S, Muratori L, Fregnan F, Manfredi M, Bertolo R, Porpiglia F.  Strategies to improve nerve regeneration after radical prostatectomy: a narrative review.  Minerva Urol Nefrol. 2018 Jul 23. doi: 10.23736/S0393-2249.18.03157-0. [Epub ahead of print] PubMed PMID: 30037210.

Marchesini A, Raimondo S, Zingaretti N, Riccio V, Battiston B, Provinciali M, Geuna S, Riccio M.  The amnion muscle combined graft (AMCG) conduits in nerves repair: an anatomical and experimental study on a rat model.  J Mater Sci Mater Med. 2018 Jul 21;29(8):120. doi: 10.1007/s10856-018-6126-5. PubMed PMID: 30032327.

Ronchi G, Fornasari BE, Crosio A, Budau CA, Tos P, Perroteau I, Battiston B, Geuna S, Raimondo S, Gambarotta G.  Chitosan Tubes Enriched with Fresh Skeletal Muscle Fibers for Primary Nerve Repair.  Biomed Res Int. 2018 Jun 13;2018:9175248. doi: 10.1155/2018/9175248. eCollection 2018. PubMed PMID: 30009176; PubMed Central PMCID: PMC6020668.

El Soury M, Fornasari BE, Morano M, Grazio E, Ronchi G, Incarnato D, Giacobini M, Geuna S, Provero P, Gambarotta G.  Soluble Neuregulin1 Down-Regulates Myelination Genes in Schwann Cells.  Front Mol Neurosci. 2018 May 14;11:157. doi: 10.3389/fnmol.2018.00157. eCollection 2018. PubMed PMID: 29867349; PubMed Central PMCID: PMC5960709.

Carriel V, Geuna S, Alaminos M.  Ex Vivo and In Vivo Stem Cells-Based Tissue Engineering Strategies for Their Use in Regenerative Medicine.  Stem Cells Int. 2018 Apr 15;2018:7143930. doi: 10.1155/2018/7143930. eCollection 2018. PubMed PMID: 29760733; PubMed Central PMCID: PMC5924978.

Muratori L, Gnavi S, Fregnan F, Mancardi A, Raimondo S, Perroteau I, Geuna S.  Evaluation of Vascular Endothelial Growth Factor (VEGF) and Its Family Member Expression After Peripheral Nerve Regeneration and Denervation.  Anat Rec (Hoboken). 2018 Apr 30. doi: 10.1002/ar.23842. [Epub ahead of print] PubMed PMID: 29710417.

Gnavi S, Morano M, Fornasari BE, Riccobono C, Tonda-Turo C, Zanetti M, Ciardelli G, Gambarotta G, Perroteau I, Geuna S, Raimondo S.  Combined Influence of Gelatin Fibre Topography and Growth Factors on Cultured Dorsal Root Ganglia Neurons.  Anat Rec (Hoboken). 2018 Apr 30. doi: 10.1002/ar.23846. [Epub ahead of print] PubMed PMID: 29710414.

Morano M, Ronchi G, Nicolò V, Fornasari BE, Crosio A, Perroteau I, Geuna S, Gambarotta G, Raimondo S.  Modulation of the Neuregulin 1/ErbB system after skeletal muscle denervation and reinnervation.  Sci Rep. 2018 Mar 22;8(1):5047. doi: 10.1038/s41598-018-23454-8. PubMed PMID: 29568012; PubMed Central PMCID: PMC5864756.

Fornasari BE, Ronchi G, Pascal D, Visigalli D, Capodivento G, Nobbio L, Perroteau I, Schenone A, Geuna S, Gambarotta G.  Soluble Neuregulin1 is strongly up-regulated in the rat model of Charcot-Marie-Tooth 1A disease.   Exp Biol Med (Maywood). 2018 Feb;243(4):370-374. doi: 10.1177/1535370218754492. Epub 2018 Jan 19. PubMed PMID: 29350067.

Carvalho C. R., Wrobel S, Meyer C, Brandenberger C, Cengiza I. F. López-Cebral R, Silva-Correia J, Ronchi G, Reis R. L., Grothe C. Oliveira J. M., Haastert-Talini K.  The Potential of Gellan Gum-based Luminal Fillers for Peripheral Nerve Regeneration. An In Vivo Study in the Rat Sciatic Nerve Repair Model.  Biomaterial Science. 2018, 6, 1059

Popara J, Accomasso L, Vitale E, Gallina C, Roggio D, Iannuzzi A, Raimondo S, Rastaldo R, Alberto G, Catalano F, Martra G, Turinetto V, Pagliaro P, Giachino C.  Silica nanoparticles actively engage with mesenchymal stem cells in improving acute functional cardiac integration.  Nanomedicine (Lond). 2018 May; 13(10):1121-1138. doi: 10.2217/nnm-2017-0309. Epub 2018 Jun 8.

2017

Ronchi G, Cillino M, Gambarotta G, Fornasari BE, Raimondo S, Pugliese P, Tos P, Cordova A, Moschella F, Geuna S. Irreversible changes occurring in long-term denervated Schwann cells affect delayed nerve repair. J Neurosurg. 2017 Jan 6:1-14. doi: 10.3171/2016.9.JNS16140. [Epub ahead of print]

Ribeiro J, Caseiro AR, Pereira T, Armada-da-Silva PA, Pires I, Prada J, Amorim I, Leal Reis I, Amado S, Santos JD, Bompasso S, Raimondo S, Varejão AS, Geuna S, Luís AL, Maurício AC. Evaluation of PVA biodegradable electric conductive membranes for nerve regeneration in axonotmesis injuries: the rat sciatic nerve animal model. J Biomed Mater Res A. 2017 Jan 12. doi: 10.1002/jbm.a.35998. [Epub ahead of print]

Carriel V, Campos A, Alaminos M, Raimondo S, Geuna S. Staining Methods for Normal and Regenerative Myelin in the Nervous System. Methods Mol Biol. 2017;1560:207-218. doi: 10.1007/978-1-4939-6788-9_15.

Onger ME, Kaplan S, Deniz ÖG, Altun G, Altunkaynak BZ, Balcı K, Raimondo S, Geuna S. Possible promoting effects of melatonin, leptin and alcar on regeneration of the sciatic nerve. J Chem Neuroanat. 2017 Feb 3;81:34-41. doi: 10.1016/j.jchemneu.2017.02.003. [Epub ahead of print]

Mazzara PG, Massimino L, Pellegatta M, Ronchi G, Ricca A, Iannielli A, Giannelli SG, Cursi M, Cancellieri C, Sessa A, Del Carro U, Quattrini A, Geuna S, Gritti A, Taveggia C, Broccoli V. Two factor-based reprogramming of rodent and human fibroblasts into Schwann cells. Nat Commun. 2017 Feb 7;8:14088. doi: 10.1038/ncomms14088.

2016

Meyer C, Stenberg L, Gonzalez-Perez F, Wrobel S, Ronchi G, Udina E, Suganuma S, Geuna S, Navarro X, Dahlin LB, Grothe C, Haastert-Talini K. Chitosan-film enhanced chitosan nerve guides for long-distance regeneration of peripheral nerves. Biomaterials. 2016 Jan;76:33-51. doi: 0.1016/j.biomaterials.2015.10.040.

Papalia I, Magaudda L, Righi M, Ronchi G, Viano N, Geuna S, Colonna MR. Epineurial Window Is More Efficient in Attracting Axons than Simple Coaptation in a Sutureless (Cyanoacrylate-Bound) Model of End-to-Side Nerve Repair in the Rat Upper Limb: Functional and Morphometric Evidences and Review of the Literature. PLoS One. 2016 Feb 12;11(2):e0148443. doi: 10.1371/journal.pone.0148443.

Fregnan F, Ciglieri E, Tos P, Crosio A, Ciardelli G, Ruini F, Tonda-Turo C, Geuna S, Raimondo S. Chitosan crosslinked flat scaffolds for peripheral nerve regeneration. Biomed Mater. 2016 Aug 10;11(4):045010. doi: 10.1088/1748-6041/11/4/045010.

Gnavi S, Fornasari BE, Tonda-Turo C, Laurano R, Zanetti M, Ciardelli G, Geuna S. In vitro evaluation of gelatin and chitosan electrospun fibers as artificial guide in peripheral nerve repair: a comparative study. J Tissue Eng Regen Med. 2016 Nov 12. doi: 10.1002/term.2351. [Epub ahead of print]

Fornasari BE, El Soury M, De Marchis S, Perroteau I, Geuna S, Gambarotta G. Neuregulin1 alpha activates migration of neuronal progenitors expressing ErbB4. Mol Cell Neurosci. 2016 Oct 27. pii: S1044-7431(16)30206-8. doi: 10.1016/j.mcn.2016.10.008. [Epub ahead of print]

Geuna S, Raimondo S, Fregnan F, Haastert-Talini K, Grothe C. In vitro models for peripheral nerve regeneration. Eur J Neurosci. 2016 Feb;43(3):287-96. doi: 10.1111/ejn.13054. Epub 2015 Sep 28. Review. PubMed PMID: 26309051. IF 2,975 Q2
Tos P, Crosio A, Pellegatta I, Valdatta L, Pascal D, Geuna S, Cherubino M. Efficacy of anti-adhesion gel of carboxymethylcellulose with polyethylene oxide on peripheral nerve: Experimental results on a mouse model. Muscle Nerve. 2016 Feb;53(2):304-9. doi: 10.1002/mus.24739. Epub 2015 Aug 8. PubMed PMID: 26082205. IF 2,713 Q2

Ronchi G, Haastert-Talini K, Fornasari BE, Perroteau I, Geuna S, Gambarotta G. The Neuregulin1/ErbB system is selectively regulated during peripheral nerve degeneration and regeneration. Eur J Neurosci. 2016 Feb;43(3):351-64. doi: 10.1111/ejn.12974. Epub 2015 Jul 8. PubMed PMID: 26061116. IF 2,975 Q2

Shapira Y, Tolmasov M, Nissan M, Reider E, Koren A, Biron T, Bitan Y, Livnat, M, Ronchi G, Geuna S, Rochkind S. Comparison of results between chitosan hollow tube and autologous nerve graft in reconstruction of peripheral nerve defect: An experimental study. Microsurgery. 2016 Nov;36(8):664-671. doi: 10.1002/micr.22418. Epub 2015 Apr 22. PubMed PMID: 25899554. IF 2,054 Q2

Meyer C, Wrobel S, Raimondo S, Rochkind S, Heimann C, Shahar A, Ziv-Polat O, Geuna S, Grothe C, Haastert-Talini K. Peripheral Nerve Regeneration Through Hydrogel-Enriched Chitosan Conduits Containing Engineered Schwann Cells for Drug Delivery. Cell Transplant. 2016;25(1):159-82. doi: 10.3727/096368915X688010. Epub 2015 Apr 14. PubMed PMID: 25876520. IF 3,427 Q3