Michele Simonato, University of Ferrara

Share on
Event date: 16/03/2017

Thursday, 16th March - h 11:30 a.m.
 Seminars Room, NICO

Meta-analysis of microRNAs dysregulated in the hippocampal dentate gyrus of animal models of epilepsy

Michele Simonato, MD, PhD
University of Ferrara – Department of Medical Sciences – Section of Pharmacology - Ferrara
Sant'Anna Hospital – Clinical Pharmacology Unit - Ferrara
University Vita-Salute San Raffaele - Division of Neuroscience – Milano

The identification of biomarkers of the transformation of normal to epileptic tissue would help to stratify patients at risk of epilepsy following brain injury, and inform new treatment strategies. MicroRNAs (miRNAs) are an attractive option in this direction. We performed miRNA microarrays on laser-microdissected hippocampal granule cell layer and on plasma, at different time points in the development of pilocarpine-induced epilepsy in the rat. This study suggests a role for miRNAs in the development of epilepsy (epileptogenesis).

However, individual studies are underpowered to detect the full spectrum of miRNA changes associated with epilepsy. Therefore, we undertook a meta-analysis of changes in miRNA expression in the hippocampal dentate gyrus following an epileptogenic insult in three experimental models of acquired epilepsy. This further study identified new miRNAs associated with epileptogenesis and epilepsy, highlighting the utility of meta-analysis in maximizing value from existing animal model data.

Host: Alessandro Vercelli


Events & Meetings

27 february 2020


University of Turin, Italy   
The Workshop is aimed at PhD students and young Postdocs with the goal to promote a thorough understanding of the functions of glial cells in health and disease. The program includes lectures on the newest conceptual advancements and methodological approaches in the study of glial cells in synaptic functions, development and CNS diseases.

Deadline for registration: December 23, 2019.

29 november 2019

NICO Progress Report - INN Open Neuroscience Forum 2019

Our young researchers present their work to collegues. From January to December, every two weeks, on friday at 2:00 pm
Seminars Room, NICO

14 november 2019

BraYn 2019 Milan, 14-16 November

The main goal of the BraYn initiative is to organize a scientific conference involving different laboratories across Italy and Europe where young researchers, especially PhD students and junior postdocs, can share their knowledge, skills and ideas to establish new collaborations between different research groups.