Friday, 26th May - h. 14:00
Seminars Room, NICO
Neuronal signalling pathway responsiveness to temporally-encoded inputs - new insights and new tools
NMDA receptors (NMDAR) are the main calcium-conducting channels gated by neurotransmitter glutamate in the brain. They play critical roles in the pathological mechanisms of a broad range of neurological conditions as well as normal brain function. This complicates the druggability of NMDA receptors, and emphasises the importance of identifying druggable signalling mechanisms downstream of the receptors.
In this talk I will focus on mechanisms by which NMDA receptors activate mitogen-activated protein kinases (MAPKs), in particular p38. We recently found that the protein interactions underlying these mechanisms are sufficient to result in distinct outputs depending on the temporal encoding of inputs. To more precisely address the temporal aspects of signalling pathways we recently developed novel cellular optogenetic inhibitors of MAPKs. Use of these tools has revealed that intracellular signalling circuits in neurons exhibit unexpected sensitivities to periodic inhibition of signalling, akin to circuit resonance previously identified only in microbial cells.
Our results indicate that improving our understanding of the kinetic aspects of signalling circuits may be crucial for identification of druggable targets and development of inhibitory strategies.
Host: Alessandro Vercelli
Events & Meetings
University of Turin, Italy
The Workshop is aimed at PhD students and young Postdocs with the goal to promote a thorough understanding of the functions of glial cells in health and disease. The program includes lectures on the newest conceptual advancements and methodological approaches in the study of glial cells in synaptic functions, development and CNS diseases.
Deadline for registration: December 23, 2019.
Our young researchers present their work to collegues. From January to December, every two weeks, on friday at 2:00 pm
Seminars Room, NICO
The main goal of the BraYn initiative is to organize a scientific conference involving different laboratories across Italy and Europe where young researchers, especially PhD students and junior postdocs, can share their knowledge, skills and ideas to establish new collaborations between different research groups.