Marion Betizeau, Brain Research Institute - University of Zurich

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Event date: 26/10/2017

PhD Program in Neuroscience, University of Turin

Friday, 27th October - h. 14:00
Seminars Room, NICO

Marion Betizeau
Brain Research Institute, University of Zurich - Switzerland

Higher diversity of primate cortical precursors revealed by unsupervised lineage-based classification

The development of the primate cortex is characterized by the diversity of cortical precursors and the complexity of their lineage relationships. Previous manual classifications of precursors relied only on morphological parameters. In this talk I will present an unsupervised lineage-based clustering method using Hidden Markov Tree (HMT) models. 

Applied to a database of macaque cortical lineage trees, the algorithm automatically extracts precursor types based on their morphology, proliferative behavior and originally also based on the fate of their progeny. This approach highlights a higher diversity of macaque precursor types than previously assumed and stochastic lineage relationships between these types. Moreover, the HMT model is a valuable tool to investigate fundamental questions in development, namely the number of precursor types and the directionality of the differentiation process.

Host: Annalisa Buffo

Events & Meetings

14 february 2020

NICO Progress Report

Our young researchers present their work to collegues. From January to December, every two weeks, on friday at 2:00 pm
Seminars Room, NICO

27 february 2020


University of Turin, Italy   
The Workshop is aimed at PhD students and young Postdocs with the goal to promote a thorough understanding of the functions of glial cells in health and disease. The program includes lectures on the newest conceptual advancements and methodological approaches in the study of glial cells in synaptic functions, development and CNS diseases.