Neuroendocrinologia

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Gruppo guidato da Giancarlo Panzica

Neuroendocrinologia
Brigitta Bonaldo

Brigitta Bonaldo

PostDoc Fellow

Contacts:

e-mail: brigitta.bonaldo@unito.it

Curriculum Vitae

Born in Turin (TO) on 30/01/1992 - Italian.

Current Position: Post-doctoral Fellow - Neuroendocrinology Unit, Dept. of Neuroscience and Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin - Italy. 

Education

2022 – PhD in Neuroscience, Doctoral School in Life and Health Sciences, University of Turin.

2016 - Master’s Degree in Cellular and Molecular Biology, Neurobiological Curriculum [LM-6] at the University of Turin (A.A. 2015-2016).

2014 - Bachelor’s Degree in Biotechnology [L-2] at the University of Turin (A.A. 2013-2014).

Academic training and research experiences

April 2022 – today: Post-doctoral fellowship, Department of Neuroscience “Rita Levi Montalcini” University of Turin. Supervisor: Prof. Stefano Gotti, Department of Neuroscience”Rita Levi Montalcini”, University of Turin, Turin, Italy.

January – March 2022: Research Scholarships by CRT Foundation (Dep. Neuroscience, University of Turin). Supervisor: Prof. GianCarlo Panzica.

October 2017 – December 2021: PhD attendance in Professor Panzica’s laboratory at the Neuroscience Institute Cavalieri Ottolenghi (N.I.C.O.) and Neuroendocrinology Unit, University of Turin & AOU San Luigi Gonzaga, Orbassano (TO).

17-18 February 2020: training on performing maternal behavior at Behavioral Biology Laboratory headed by Professor Paola Palanza, University of Parma (Italy).

25-31 August 2019: attendance of IPBS “International Summer School on Endocrine Disruptors” - Sorbonne Université, Institute de Biologie Pierre et Marie Curie, Paris (France).

20-2 May, 2019: 45th Workshop of the International School of Ethology "Danilo Mainardi” “Sex differences, dimorphism, divergences-impact on brain and behavior in health and disease”. Erice (Italy).

25-26 October 2018: Workshop “Phthalates and bisphenol A biomonitoring in Italian mother-child pairs: link between exposure and juvenile diseases - European project LIFE PERSUADED”, Roma (Italy).

December 2016 - September 2017: voluntary internship in Professor Panzica’s laboratory at the Neuroscience Institute Cavalieri Ottolenghi (N.I.C.O.) and Neuroendocrinology Unit, University of Turin & AOU San Luigi Gonzaga, Orbassano (TO).

March 2013 - October 2016: first and second level degree internship in the Dr Bertolotto's laboratory at the Neuroscience Institute Cavalieri Ottolenghi (N.I.C.O.) and Neurobiology Unit, Neurologia 2 – CReSM (Regional Referring Center of Multiple Sclerosis), University of Turin & AOU San Luigi Gonzaga, Orbassano (TO).

Awards and scholarships

2022: 94th National Congress of the Italian Society of Experimental Biology (SIBS) – Young Investigator Award (Neurodegeneration and neuroinflammation session) (Turin, 06-09 April 2022).

2017 – 2021: PhD scholarship granted by the University of Turin.

2020 - FENS-IBRO/PERC grant- FENS2020 Virtual Forum (11-15 July 2020).

2019 - One of the 16 Post-docs or PhD students selected to attend the “IPBS International Summer School on Endocrine Disruptors” - Sorbonne Université, Institute de Biologie Pierre et Marie Curie (Paris, 25-31 August 2019).

2019 - 10th International Meeting on Steroids and Nervous System - Excellent Poster Award (Turin, 16-20 February 2019).

2018 - XXVIII Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia(G.I.S.N) - Travel grant (Florence, 30 Novembre - 01 December 2018).

Publications

M.Marraudino, B. Bonaldo, B. Vitiello, G.C. Bergui, GC. Panzica (2022) “Sexual differences in Internet Gaming Disorder (IGD): from psychological features to neuroanatomical networks” – Journal of Clinical Medicine, 11, 1018. [https:// doi.org/10.3390/jcm11041018]

B.Bonaldo, A.Casile, M.Bettarelli, S. Gotti, GC. Panzica, M.Marraudino (2021) “Effects of chronic exposure to bisphenol A in adult female mice on social behavior, vasopressin system, and estrogen membrane receptor (GPER1)” - European Journal of Histochemistry, Vol. 65 No. s1 2021. [https://doi.org/10.4081/ejh.2021.3272]

Perga S., Montarolo F., Martire S., Bonaldo B., Bono G., Bertolo J., Magliozzi R., Bertolotto A. (2021) “Overespression of the ubiquitin-editing enzyme A20 in the brain lesions of Multiple Sclerosis patients: moving form systemic to central nervous system inflammation” Brain Pathology Oct 14;e12906 [doi: 10.1111/bpa.12906]

M. Marraudino, B.Carrillo, B.Bonaldo, R. Llorente, E. Campioli, I.Garate, H. Pinos, L.M. Garcia-Segura, P. Collado, D. Grassi (2021) “G protein-coupled estrogen receptor immunoreactivity in the rat hypothalamus is widely distributed in neurons, astrocytes and oligodendrocytes, fluctuates during the estrous cycle and is sexually dimorphic” Neuroendocrinology [doi: 10.1159/000509583]

Ricardo Llorente, MarilenaMarraudino, Beatriz Carrillo, BrigittaBonaldo, Julia Simon-Areces, Pedro Abellanas-Pérez, Marina Rivero-Aguilar, Jose M.Fernandez-Garcia, Helena Pinos, Luis Miguel Garcia-Segura, Paloma Collado, Daniela Grassi (2020) “G protein-coupled estrogen receptor immunoreactivity fluctuates during the estrous cycle and show sex differences in the amygdala and dorsal hippocampus” Frontiers in Endocrinology 11:537 [DOI: 10.3389/fendo.2020.00537]

M. Marraudino, B. Bonaldo, A. Farinetti, GC. Panzica, G. Ponti, S. Gotti (2019) “Metabolic disrupting chemicals and alteration of neuroendocrine circuits controlling food intake and energy metabolism” Frontiers in Endocrinology 9:766 [doi: 10.3389/fendo.2018.00766]

Congress Abstract – Bonaldo B., Casile A., Ostuni M.T., Bettarelli M., Gotti S., Marraudino M., Panzica G. - “Perinatal exposure to bisphenol A or S alters anxiety-related behaviors and serotoninergic system in mice” - Vol. 65 No. s3 (2021): 31st National Conference of the Italian Group for the Study of Neuromorphology “Gruppo Italiano per lo Studio dellaNeuromorfologia” G.I.S.N. https://doi.org/10.4081/ejh.2021.3363

Congress Abstract – Bonaldo B., Casile A., Bettarelli M., Gotti S., Marraudino M., Panzica G.- “Effects of perinatal exposure to bisphenol A or S on sexual behavior and kisspeptin system in mice” - Vol. 65 No. s3 (2021): 31st National Conference of the Italian Group for the Study of Neuromorphology “Gruppo Italiano per lo Studio dellaNeuromorfologia” G.I.S.N. https://doi.org/10.4081/ejh.2021.3363

Congress Abstract – Nasini S., Bonaldo B.,Moussu C., Macchi E., Ponti G., Keller M., Panzica G.,  Marraudino M. - “Genistein: sexually dimorphic effects on serotonergic system in mice” - Vol. 65 No. s3 (2021): 31st National Conference of the Italian Group for the Study of Neuromorphology “Gruppo Italiano per lo Studio dellaNeuromorfologia” G.I.S.N. https://doi.org/10.4081/ejh.2021.3363

Congress Abstract - B.Bonaldo,M.Marraudino, A.Casile, M.Bettarelli, S. Gotti, GC. Panzica - “Effects of chronic exposure to bisphenol A in pregnant female mice” - Vol. 64 No. s3 (2020): 30th National Conference of the Italian Group for the Study of Neuromorphology “Gruppo Italiano per lo Studio dellaNeuromorfologia” G.I.S.N. https://doi.org/10.4081/ejh.2020.3200

Congress Abstract - V. Gaidano, P. Circosta, A. Cignetti, M. Houshmand, N. Vitale, S. Sainas, A. Pippione, M. Marraudino, B. Bonaldo, M. Giorgis, D. Boschi, M.L. Lolli, G. Saglio - “Meds433, a New Dihydroorotate Dehydrogenase Inhibitor, Induces Apoptosis and Differentiation in Acute Myeloid Leukemia” 61st ASH (American Society of Hematology) Annual Meeting and Exposition, Orlando (USA), 07-10 December 2019. Blood (2019) 134 (Supplement_1):3942 - DOI: 10.1182/blood-2019-128085

Congress Abstract - Panzica GC., Bonaldo B., Farinetti A., Marraudino M., Ponti G., Gotti S. - “Special Lecture: Effects of Endocrine Disruptors on neural circuits and behavior” Vol. 64 No. s1 (2020): 29th National Congress of the of the Italian Group for the Study of Neuromorphology “Gruppo Italiano per lo Studio dellaNeuromorfologia” G.I.S.N., Bari, November 15-16, 2019https://doi.org/10.4081/ejh.2020.3121

Congress Abstract - G. Ponti, E.Bo, A. Farinetti, M. Marraudino, B. Bonaldo, GC. Panzica,Gotti S. - “Tributyltin (TBT) alters the development of brain circuits controlling food intake” - Vol. 64 No. s1 (2020): 29th National Congress of the of the Italian Group for the Study of Neuromorphology “Gruppo Italiano per lo Studio dellaNeuromorfologia” G.I.S.N., Bari, November 15-16, 2019https://doi.org/10.4081/ejh.2020.3121

>  Curriculum Vitae

Publications:

> PubMed.gov 

News

Esposizione cronica al bisfenolo A in gravidanza: come le plastiche possono alterare encefalo e comportamento sociale

L’esposizione cronica per un periodo che copre gravidanza e allattamento, a una dose di BPA pari a quella indicata come dose tollerabile giornaliera (TDI) dall’EFSA (European Food Safety Authority) causa nelle femmine di topo alterazioni sia a livello comportamentale che encefalico.
I risultati dello studio realizzato dai nostri ricercatori del gruppo di Neuroendocrinologia e pubblicati sull’European Journal of Histochemistry suggeriscono quanto sia urgente adottare misure più stringenti nell'utilizzo di BPA, a tutela della salute di tutti.  

12 Gennaio 2022

Sclerosi multipla: lesioni del tessuto cerebrale associate a un'alterazione della proteina A20

In questo studio pubblicato su Brain Pathology le nostre ricercatrici del laboratorio di Neurobiologia clinica hanno analizzato per la prima volta l’espressione di A20 in tessuti cerebrali post-mortem di persone con SM, confrontandola con quella di tessuti di persone senza SM.

21 Gennaio 2021

GPER: il recettore degli estrogeni che fluttua con gli ormoni

Interagiscono con i loro recettori cellulari nello stesso modo in cui una chiave entra in una serratura: sono i recettori degli estrogeni (ER), ampiamente diffusi nel nostro organismo e anche nell’encefalo. Il perfetto incastro tra gli estrogeni e i loro recettori innesca una serie di eventi biochimici che culminano nella regolazione di determinate zone attive del DNA cellulare, responsabili a loro volta della sintesi delle proteine, controllando così funzioni importanti come fertilità, metabolismo, ciclo sonno/veglia, memoria e stati d’ansia.

Questa regolazione avviene per mezzo di recettori nucleari degli estrogeni noti e studiati da molto tempo. Recentemente però è stato identificato un nuovissimo recettore per gli estrogeni: GPER. Le nostre ricercatrici del gruppo di Neuroendocrinologia ne hanno approfondito in due studi la distribuzione nell’encefalo, suggerendo che la regolazione degli estrogeni attraverso il recettore GPER può essere diversa nei maschi e nelle femmine e può fluttuare durante il ciclo estrale nelle femmine.

9 Novembre 2020