Neurophysiology of neurodegenerative diseases

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Group leader:  Filippo Tempia

Neurophysiology of neurodegenerative diseases

Publications

2018

Hoxha E, Balbo I, Miniaci MC, Tempia F (2018) Purkinje cell signaling deficits in animal models of ataxia . Front. Synaptic Neurosci. 10:6 (17 pages). eCollection 2018. Review. http://dx.doi.org/10.3389/fnsyn.2018.00006.

Cerrato V, Mercurio S, Leto K, Fucà E, Hoxha E, Bottes S, Pagin M, Milanese M, Ngan C-Y, Concina G, Ottolenghi S, Wei C-L, Bonanno G, Pavesi G, Tempia F, Buffo A, Nicolis SK (2018) Sox2 conditional mutation in mouse causes ataxic symptoms, cerebellar vermis hypoplasia, and postnatal defects of Bergmann glia. Glia. http://dx.doi.org/10.1002/glia.23448.

2017

Hoxha E, Gabriele RMC, Balbo I, Ravera F, Masante L, Zambelli V, Albergo C, Mitro N, Caruso D, Di Gregorio E, Brusco A, Borroni B, Tempia F. Motor Deficits and Cerebellar Atrophy in Elovl5 Knock Out Mice. Front Cell Neurosci. 2017 Oct 30;11:343. doi: 10.3389/fncel.2017.00343. eCollection 2017.

Hoxha E, Lippiello P, Scelfo B, Tempia F, Ghirardi M, Miniaci MC. (2017) Maturation and refinement of cerebellar cortical circuits in normal development and in murine models of autism . Neural Plasticity, Article ID 2017:6595740, 14 pages. Review. doi: 10.1155/2017/6595740.

Manes M, Alberici A, Di Gregorio E, Boccone L, Premi E, Mitro N, Pasolini MP, Pani C, Paghera B, Perani D, Orsi L, Costanzi C, Ferrero M, Zoppo A, Tempia F, Caruso D, Grassi M, Padovani A, Brusco A, Borroni B (2017) DHA is a beneficial replacement treatment for Spinocerebellar Ataxia 38 (SCA38) . Ann Neurol. 2017 Oct 4. doi: 10.1002/ana.25059.

2016

Eriola Hoxha, Filippo Tempia, Pellegrino Lippiello, Maria Concetta Miniaci. (2016) Modulation, plasticity and pathophysiology of the parallel fiber-Purkinje cell synapse . Frontiers in Synaptic Neuroscience 8:35; doi: http://dx.doi.org/10.3389/fnsyn.2016.00035

Alshammari TK,Alshammari MA, Nenov MN, Hoxha E, Cambiaghi M, Marcinno A, James TF, Singh P, Labate D, Li J, Meltzer HY, Sacchetti B, Tempia F, Laezza F. Genetic deletion of fibroblast growth factor 14 recapitulates phenotypic alterations underlying cognitive impairment associated with schizophrenia . Transl Psychiatry (2016) 6, e806; http://dx.doi.org/10.1038/tp.2016.66

Barbara Borroni, Eleonora Di Gregorio, Laura Orsi, Giovanna Vaula, Chiara Costanzi, Filippo Tempia, Nico Mitro, Donatella Caruso, Marta Manes, Lorenzo Pinessi, Alessandro Padovani, Alfredo Brusco, Loredana Boccone (2016) Clinical and neuroradiological features of spinocerebellar ataxia 38 (SCA38) . Parkinsonism & Related Disorders; http://dx.doi.org/10.1016/j.parkreldis.2016.04.030

Cupolillo D, Hoxha E, Faralli A, De Luca A, Tempia F, Rossi F, Carulli D (2016) Autistic-like traits and cerebellar dysfunction in Purkinje cell PTEN knock-out mice. Neuropsychopharmacol doi: 10.1038/npp.2015.339

Lippiello Pellegrino, Hoxha Eriola, Speranza Luisa, Volpicelli Floriana, Ferraro Angela, Leopoldo Marcello, Lacivita Enza, Perrone-Capano Carla, Tempia Filippo and Miniaci Maria Concetta. (2016) The 5-HT7 Receptor Triggers Cerebellar Long-Term Synaptic Depression via PKC-MAPK . J Neuropharmacol 101: 426-438. http://dx.doi.org/10.1016/j.neuropharm.2015.10.019

2015

Sadallah M, Labat-Gest V, Tempia F.  Propagation of neuronal damage to embryonic grafts transplanted in the hippocampus of murine models of Alzheimer's disease.  Rejuvination Res. (Instant Online ahead of print June 2, 2015) 

Tempia F, Hoxha E, Negro G, Alshammari MA, Alshammari TK, Panova-Elektronova N and Laezza F (2015)  Parallel fiber to Purkinje cell synaptic impairment in a mouse model of spinocerebellar ataxia type 27 .  Front. Cell. Neurosci. 9:205. 

Sallam HS, Tumurbaatar B, Zhang WR, Tuvdendorj D, Chandalia M, Tempia F, Laezza F, Taglialatela G, Abate N. (2015)  Peripheral adipose tissue insulin resistance alters lipid composition and function of hippocampal synapses.  J Neurochem 133: 125-133.

Nenov MN, Tempia F, Denner L, Dineley KT, Laezza F. (2015)  Impaired firing properties of dentate granule neurons in an Alzheimer's disease animal model are rescued by PPARγ agonism .  J Neurophysiol 113: 1712-1726.

Lippiello P, Hoxha E, Volpicelli F, Lo Duca G, Tempia F*, Miniaci MC. (2015)  Noradrenergic Modulation of the Parallel Fiber-Purkinje Cell Synapse in Mouse Cerebellum.  Neuropharmacol 89: 33-42. DOI: 10.1016/j.neuropharm.2014.08.016. (* corresponding author)